Caspase 9 Promoter Polymorphisms (-1263G>A, -905T>G, -712C>T) in Coronary Artery Disease [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Apoptosis has been involved in a number of pathological conditions including Coronary Artery Disease (CAD). Caspases are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways.
KISHORE KUMAR GUNDAPANENI +6 more
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Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis [PDF]
BMC Cell Biology, 2013 AbstractBackgroundApoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochromecrelease is well described; however the distinct roles of caspases-9, -3 and -7 during this process are not completely defined.ResultsHere we ...
Brentnall, Matthew +4 more
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Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
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Potency of mycotoxin binders on MDA level, expressions of caspase 9 and caspase 3 in the uterus of mice exposed to zearalenone [PDF]
Iraqi Journal of Veterinary Sciences, 2017 This study examined effect of mycotoxin binder administered to female mice exposed to zearalenon on apoptosis incidence by observe at MDA, Caspase 9 and 3 levels in mice uterus.
A. Samik , E. Safitri
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Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [PDF]
PLoS Biology, 2005 Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function.
Yang Chao +5 more
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Expression and prognostic significance of APAF‐1, caspase‐8 and caspase‐9 in stage II/III colon carcinoma: Caspase‐8 and caspase‐9 is associated with poor prognosis [PDF]
International Journal of Cancer, 2010 AbstractApoptosis protease activating factor‐1 (APAF‐1), caspase‐8 and caspase‐9 are important factors in the execution of death signals. To study their prognostic influence in colon carcinoma, expression of APAF‐1, caspase‐8 and caspase‐9 was determined by immunohistochemistry in normal colon mucosa (n = 8) and R0‐resected stage II/III colon ...
Jörn, Sträter +5 more
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Mechanism of XIAP-Mediated Inhibition of Caspase-9 [PDF]
Molecular Cell, 2003 The inhibitor of apoptosis (IAP) proteins potently inhibit the catalytic activity of caspases. While profound insight into the inhibition of the effector caspases has been gained in recent years, the mechanism of how the initiator caspase-9 is regulated by IAPs remains enigmatic.
Shiozaki, Eric N +8 more
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Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]
Biochemical Journal, 2002 Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Ciara A, Ryan +5 more
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Regulation of the Apaf-1–caspase-9 apoptosome [PDF]
Journal of Cell Science, 2010 Apoptosis is probably not the only form of cell death, but it is currently the only form for which the proteins that constitute the death pathway have been characterized at the structural, biochemical and genetic levels in great detail.
Shawn B, Bratton, Guy S, Salvesen
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The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125 [PDF]
Journal of Biological Chemistry, 2008 Caspase-9 plays a critical role in the initiation of apoptosis by the mitochondrial pathway. Activation of caspase-9 is inhibited by phosphorylation at Thr(125) by ERK1/2 MAPKs in response to growth factors. Here, we show that phosphorylation of this site is specific for these classical MAPKs and is not strongly induced when JNK and p38alpha/beta MAPKs
Martin, Morag C. +3 more
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