Results 51 to 60 of about 6,274,764 (195)

Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]

Biochemical Journal, 2002
Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Ciara A, Ryan, Henning R, Stennicke, Victor E, Nava, Jennifer B, Burch, J Marie, Hardwick, Guy S, Salvesen   +5 more
openaire   +2 more sources

Upregulation of Survivin in G2/M Cells and Inhibition of Caspase 9 Activity Enhances Resistance in Staurosporine-Induced Apoptosis

Neoplasia: An International Journal for Oncology Research, 2004
Survivin, a member of the inhibitor of apoptosis (IAP) gene family, plays an important role in both the regulation of cell cycle and the inhibition of apoptosis, and is frequently overexpressed in many tumor types.
Anmol Chandele, Vandna Prasad, Jayashree C. Jagtap, Ravi Shukla, Padma R. Shastry   +4 more
doaj   +1 more source

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

Cardiovascular Diabetology, 2005
Background In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood.
Simonson Michael S, Mishra Rangnath
doaj   +1 more source

Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]

Protein Science, 2012
AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Kristen L, Huber, Jeanne A, Hardy
openaire   +2 more sources

Caspase-9 plays only a minor role in TRAIL-induced apoptosis in NCI-H460 cells.

, 2018
(A) Cells were preincubated with caspase-9 inhibitor (z-LEHD-fmk, 50 μM) for 1 h, followed by stimulation with serial dilutions of Db-scTRAIL for 24 h. Viable cells were stained with crystal violet and absorbance was measured at 550 nm.
Lubna Danish (5434982), Peter Scheurich (144993), Frank Allgöwer (5434979), Nadine Pollak (1801804), Dirke Imig (5434985)   +4 more
core   +1 more source

Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]

Proceedings of the National Academy of Sciences, 1998
Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery.
H O, Fearnhead, J, Rodriguez, E E, Govek, W, Guo, R, Kobayashi, G, Hannon, Y A, Lazebnik   +6 more
openaire   +2 more sources

Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures [PDF]

, 2010
Background The xylem vascular system is composed of fused dead, hollow cells called tracheary elements (TEs) that originate through trans-differentiation of root and shoot cambium cells. TEs undergo autolysis as they differentiate and mature.
Elena T Iakimova, Ernst J Woltering, Qian Tian, Twumasi, P., Schel Jan HN, Emons, A.M.C., Wim van Ieperen, Olaf van Kooten, van Ieperen Wim, van Kooten, O., van Ieperen, W., Iakimova, E.T., van Kooten Olaf, Qian, T., Emons Anne, Schel, J.H.N., Peter Twumasi, Tian Qian, Iakimova Elena T, Woltering, E.J., Anne Emons, Kooten, O., van, Ieperen, W., van, Anne MieC Emons, Twumasi Peter, Woltering Ernst J, Jan HN Schel   +26 more
core   +1 more source

The Effect of Diclofenac on Caspase-8 and Caspase-9 Activity in Cervical Cancer Cells (HeLa) in Cell Culture

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: Studies have shown that drugs can affect on proliferation of cancer cells. The main aim of this study was to determine the effects of diclofenac on caspase-8 and caspase-9 activity in cervical cancer cells (HeLa) in cell ...
Minoo Erfani, Masoud Ghorbani, Rahim Ahmadi   +2 more
doaj  

The expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE1/AE3 in goats with enzootic nasal adenocarcinoma: an immunohistochemical study

Veterinární Medicína, 2013
The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA).
A. Aydogan, M. Haligur, O. Ozmen
doaj   +1 more source

The Dimeric Caspase-9 Closely Resembles the WT Caspase-9

, 2013
(A) Overall structure of the dimeric caspase-9 (C287S). The structural core is shown in blue; the solvent-exposed active site loops are shown in magenta. The β6 and β6′ strands are highlighted in red. Note the asymmetry of the dimer.
Eric N Shiozaki (68540), Robert Fairman (68543), Srinivasa M Srinivasula (68541), Yang Chao (68539), Daniel J Rigotti (68542), Yigong Shi (68544)   +5 more
core   +1 more source