Results 211 to 220 of about 160,266 (354)

Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures [PDF]

, 1998
G. Bruce Pike, Xiurong Zhao, Jennifer K. Newcomb, Kevin Wang, Rand Posmantur, Ronald L. Hayes   +5 more
openalex   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Modeling Necroptotic and Pyroptotic Signaling in <i>Saccharomyces cerevisiae</i>. [PDF]

Biomolecules
Barbero-Úriz Ó, Valenti M, Molina M, Fernández-Acero T, Cid VJ.   +4 more
europepmc   +1 more source

Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin

, 1997
Claudio Brancolini, Dejan Lazarević, Joe Rodriguez, Claudio Schneider   +3 more
openalex   +1 more source

Caspases‐3 and ‐7 are activated in goniothalamin‐induced apoptosis in human Jurkat T‐cells [PDF]

, 1999
Salmaan H. Inayat‐Hussain, Annuar Bin Osman, Laily B. Din, Abdul Manaf Ali, Roger T. Snowden, Marion MacFarlane, Kelvin Cain   +6 more
openalex   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis. [PDF]

Front Cell Dev Biol
Mei J, Xiao N, Xi Y, Chen X, Zha X, Cui L, Yan F, Xue R, Wang Y, Ma Y.   +9 more
europepmc   +1 more source

Mutations in the Heparin Binding Domain of Fibronectin in Cooperation with the V Region Induce Decreases in pp125 Levels Plus Proteoglycan-mediated Apoptosis via Caspases [PDF]

, 1999
Yvonne L. Kapila, Shaohui Wang, Paul W. Johnson   +2 more
openalex   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

A tale of two caspases. [PDF]

Elife
Monack DM.
europepmc   +1 more source