Results 201 to 210 of about 80,424 (267)

A β‑1,3‑1,6‑glucan from <i>Aureobasidium pullulans</i> enhances apoptotic and autophagic pathways in colorectal cancer cells. [PDF]

Mol Med Rep
Park JW, Mun GM, Jo TM, Shin JA, Kuge T, Kimoto H, Kim JK.   +6 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

The Role of Long Non-Coding RNAs in the Pathogenesis of Coronary Heart Disease. [PDF]

Genes (Basel)
Plewa P, Kulpa J, Szulc J, Szczepanik M, Domańska M, Pawlik A.   +5 more
europepmc   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

From Nucleobases to Bioactive NHC-Based Gold and Silver Complexes With Anticancer and Antiviral Activity. [PDF]

ChemMedChem
Iacopetta D, Ceramella J, Checconi P, Frezza F, Marra M, Mariconda A, D'Amato A, Catalano A, Aquaro S, Longo P, Sinicropi MS.   +10 more
europepmc   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Life-death trade-offs: HSV-1 ICP27 differentially modulates intrinsic apoptotic signaling in epithelial and neuron-like cells. [PDF]

Front Microbiol
Nordi C, Caproni A, Barboni D, Proietto D, Facchini M, Fontana R, Buratto M, Catani M, Marconi P.   +8 more
europepmc   +1 more source

SMAD4 Expression and Its Association With Treatment Resistance and Clinical Outcomes in Oral Squamous Cell Carcinoma Treated With Preoperative Chemoradiotherapy. [PDF]

Cancer Rep (Hoboken)
Sakata J, Hirosue A, Yoshida R, Matsuoka Y, Todoroki Y, Arita H, Nakashima H, Yamamoto T, Takahashi N, Hirayama M, Kawahara K, Toya R, Murakami R, Ito T, Kuwahara Y, Nakayama H.   +15 more
europepmc   +1 more source

Systematic genetic analysis of GSDMD, GSDME, and MLKL in PANoptosis. [PDF]

J Biol Chem
Indari O, Giri P, Tweedell RE, Kanneganti TD.   +3 more
europepmc   +1 more source