Results 111 to 120 of about 650,104 (308)

Abiraterone experience in a patient with metastatic castration-resistant prostate cancer on hemodialysis [PDF]

, 2019
Abiraterone is an oral inhibitor of cytochrome P450 (17alpha)-hydroxylase/17,20 lyase (CYP17) complex critical to androgen production. Abiraterone in combination with prednisone is currently FDA approved for use in men with metastatic castration ...
Eryilmaz, Melek Karakurt, Karaagac, Mustafa   +1 more
core   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Reappraisal of glucocorticoids in castrate-resistant prostate cancer

Asian Journal of Andrology, 2014
Recent reports and discussions of preclinical prostate cancer models have emphasized the possibility that enzalutamide resistance may be mediated by glucocorticoid receptors (GR). In both in vitroand xenograft animal studies, it is possible to show that the GR is up-regulated in prostate cancer cell lines and that dexamethasone reverses enzalutamide ...
Oliver Sartor, Christopher C Parker, Johann De Bono   +2 more
openaire   +3 more sources

Castration-resistant prostate cancer: potential targets and therapies

, 2012
Aijaz Parray,1 Hifzur R Siddique,1 Sanjeev Nanda,1,2 Badrinath R Konety,3 Mohammad Saleem1,3,41Molecular Chemoprevention and Therapeutics, The Hormel Institute, University of Minnesota, Austin, 2Department of Internal Medicine, Mayo Clinic Health Systems,
Konety BR, Nanda S, Saleem M, Siddique HR, Parray A   +4 more
core  

Advances in hormonal therapies for hormone naïve and castration-resistant prostate cancers with or without previous chemotherapy

, 2016
Hormonal manipulation plays a significant role in the treatment of advanced hormone naïve prostate cancer and castration-resistant prostate cancer (CRPC) with or without previous chemotherapy. Combination of gonadotropin releasing hormone (GnRH) agonists
Richard, Kerry, d'Emden, Michael C., Li, Huika, Pham, Thy, d’Emden, Michael C., Richard, Derek J., Sadowski, Martin C.   +6 more
core   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Histone Deacetylase Inhibitors Restore Cell Surface Expression of the Coxsackie Adenovirus Receptor and Enhance CMV Promoter Activity in Castration-Resistant Prostate Cancer Cells

Prostate Cancer, 2012
Adenoviral gene therapy using the death receptor ligand TRAIL as the therapeutic transgene can be safely administered via intraprostatic injection but has not been evaluated for efficacy in patients.
Laura Kasman, Georgiana Onicescu, Christina Voelkel-Johnson   +2 more
doaj   +1 more source

Survival after docetaxel for metastatic castration-resistant prostate cancer in a rural health care setting [PDF]

Introduction: The aim of this study was to evaluate overall survival of men who received systemic therapy with docetaxel for metastatic castration- resistant prostate cancer (MCRPC) in rural Nordland County, Norway.
Nieder, Carsten, Carsten Nieder, Haukland, Ellinor Christin, Ellinor Haukland, Stanisavljevic, Luka, Astrid Dalhaug, Luka Stanisavljevic, Dalhaug, Astrid   +7 more
core   +1 more source

‘Everything is a signal’: speaking circuits and noisy signs in the making of language‐oriented AI « Tout est signal » : circuits parlants et signes bruyants dans la création de l'IA orientée langage

Journal of the Royal Anthropological Institute, EarlyView.
Contemporary artificial intelligence (AI) technologies are often presumed to be capable of revealing unmediated truths about the world, including the truths language might hold, echoing the long‐standing assertion that language's primary function is to directly translate reality.
Beth M. Semel
wiley   +1 more source

Queering Institutional Milestones in Elite Higher Education: Queer Perspectives on Princeton University and Coeducation (1960–1980)

Gender &History, EarlyView.
ABSTRACT A new archive of oral history interviews from LGBTQIA‐identified alumni, faculty and staff reveals the complex ways that queer and transgender students understood, experienced and remembered the long transition from single‐sex to coeducation at Princeton University.
Ezelle Sanford III, Judy Jarvis, Eric Anglero   +2 more
wiley   +1 more source