Results 141 to 150 of about 67,507 (290)

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Nature Communications
Castration-resistant prostate cancer is a heterogeneous disease with variable phenotypes commonly observed in later stages of the disease. These include cases that retain expression of luminal markers and those that lose hormone dependence and acquire ...
Kei Mizuno, Sheng-Yu Ku, Varadha Balaji Venkadakrishnan, Martin K. Bakht, Michael Sigouros, Joanna Chan, Anna Trigos, Jordan H. Driskill, Jyothi Manohar, Abigail King, Adam G. Presser, Min Jin Kim, Alok K. Tewari, Henry W. Long, David Quigley, Toni K. Choueiri, Steven Balk, Sarah Hill, Juan Miguel Mosquera, David Einstein, Shahneen Sandhu, Mary-Ellen Taplin, Himisha Beltran   +22 more
doaj   +1 more source

Bispecific Dual‐Immune Checkpoint Inhibitor Associated Cutaneous Toxicity: A Report of Lorigerlimab Adverse Skin Reaction in Two Cancer Patients

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Lorigerlimab is a dual bispecific antibody (BsAb) targeting cytotoxic T‐lymphocyte‐associated protein 4 and programmed cell death protein 1 that is used for treatment of advanced solid cancers such as metastatic castration‐resistant prostate carcinoma.
Niloofar Sina, Fiorinda Muhaj, Volha Lenskaya, Doina Ivan, Victor G. Prieto, Jonathan L. Curry   +5 more
wiley   +1 more source

Assessment of Different Castration Resistance Definitions and Staging Modalities in Metastatic Castration-Resistant Prostate Cancer

Cancers
Background/Objectives: Progression to metastatic castration-resistant prostate cancer (mCRPC) is defined either biochemically, radiographically or both. Moreover, staging for mCRPC can be performed either conventionally or with molecular imaging such as prostate-specific membrane antigen computer tomography (PSMA-PET/CT).
Mike Wenzel, Benedikt Hoeh, Clara Humke, Carolin Siech, Cristina Cano Garcia, Georg Salomon, Tobias Maurer, Markus Graefen, Simon Bernatz, Andreas Michael Bucher, Luis Kluth, Felix K. H. Chun, Philipp Mandel   +12 more
openaire   +2 more sources

Drastic Response to Olaparib in a Patient With Metastatic Castration-Resistant Prostate Cancer Harboring BRCA2 Alterations and Near-Threshold Tumor Mutational Burden. [PDF]

IJU Case Rep
ABSTRACT Introduction BRCA2 alterations and high tumor mutational burden (TMB‐H) are responsible for prostate cancer; however, their co‐occurrence is uncommon, and evidence for PARP inhibition in the castration‐sensitive setting remains limited. We describe a case of metastatic castration‐resistant prostate cancer (CRPC) harboring both biomarkers ...
Yokota K, Kosaka T, Daimon T, Fujiwara S, Nakamura K, Nishihara H, Oya M.   +6 more
europepmc   +2 more sources

From Unremembered to Overremembered. Gender in the Holocaust Museums of Hungary and Slovakia

Curator: The Museum Journal, EarlyView.
ABSTRACT In museums, the history of the Holocaust is told through various means of exhibition construction, including architecture/space, texts, artifacts, photographs, and digital technologies. The article focuses on the gendered history of the Holocaust in museums as institutions in Central Europe after the illiberal turn and evaluates how (and if ...
Andrea Petö, Borbála Klacsmann
wiley   +1 more source

Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy

EMBO Molecular Medicine
A critical knowledge gap in prostate cancer research is understanding whether castration-tolerant progenitor-like cells that reside in treatment-naïve tumors play a direct role in therapy resistance and tumor progression.
Manon Baurès, Anne-Sophie Vieira Aleixo, Emeline Pacreau, Aysis Koshy, Vanessa Friedrich, Marc Diedisheim, Martin Raigel, Yichao Hua, Charles Dariane, Florence Boutillon, Lukas Kenner, Jean-Christophe Marine, Gilles Laverny, Daniel Metzger, Florian Rambow, Jacques-Emmanuel Guidotti, Vincent Goffin   +16 more
doaj   +1 more source

Castration Resistance [PDF]

, 2020
openaire   +1 more source

Balancer‐assisted sling recovery of critical equine patients after general anaesthesia

Equine Veterinary Education, EarlyView.
Summary Background Traditional sling‐based systems to assist horses during recovery from general anaesthesia (GA) could be improved by adding a balancer to obtain a dynamic weight relief. Objectives To evaluate the applicability of a novel balancer‐assisted sling system during recovery of horses after GA and to report initial experiences with high‐risk
J. Kuhlmann, C. Spadavecchia, C. Koch
wiley   +1 more source

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

The Journal of Clinical Investigation
Mediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming, are differentially regulated by androgen signaling, but both kinases are upregulated in castration-resistant prostate cancer (CRPC).
Jing Li, Thomas A. Hilimire, Yueying Liu, Lili Wang, Jiaxin Liang, Balazs Gyorffy, Vitali Sikirzhytski, Hao Ji, Li Zhang, Chen Cheng, Xiaokai Ding, Kendall R. Kerr, Charles E. Dowling, Alexander A. Chumanevich, Zachary T. Mack, Gary P. Schools, Chang-uk Lim, Leigh Ellis, Xiaolin Zi, Donald C. Porter, Eugenia V. Broude, Campbell McInnes, George Wilding, Michael B. Lilly, Igor B. Roninson, Mengqian Chen   +25 more
doaj   +1 more source

Synthetic DNA immunotherapy in biochemically relapsed prostate cancer [PDF]

, 2018
Background: INO-5150 (PSA and PSMA) +/- INO-9012 (IL-12), a synthetic DNA immunotherapy, was assessed for safety, immunogenicity and efficacy in biochemically recurrent prostate cancer patients (pts).
Appleman, L. J., Bagarazzi, M. L., Bhatt, K., Cheng, H., Csiki, I., Garcia, J., Heath, E. I., Kelly, W., Kraynyak, K., Lee, J., Liu, L., McMullan, T., Morrow, M., Nordquist, L. T., Rosencranz, S., Sacchetta, B., Shore, N., Tagawa, S. T., Tutrone, R., Whang, Y.   +19 more
core   +1 more source