Results 81 to 90 of about 67,507 (290)

Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen. [PDF]

PLoS ONE, 2012
As prostate cancer progresses to castration-resistant disease, there is an increase in signal transduction activity. Most castration-resistant prostate tumors continue to express the androgen receptor (AR) as well as androgen-responsive genes, despite ...
Hilary Whitworth, Shriti Bhadel, Melissa Ivey, Mark Conaway, Andrea Spencer, Ronald Hernan, Heather Holemon, Daniel Gioeli   +7 more
doaj   +1 more source

Novel actions of next-generation taxanes benefit advanced stages of prostate cancer. [PDF]

, 2015
PURPOSE: To improve the outcomes of patients with castration-resistant prostate cancer (CRPC), there is an urgent need for more effective therapies and approaches that individualize specific treatments for patients with CRPC.
Berman-Booty, Lisa D., Ciment, Stephen J, de Leeuw, Renée, Den, Robert, Dicker, Adam P., Gomella, Leonard G., Kelly, William, Knudsen, Karen E., Lallas, Costas D., Schiewer, Matthew J., Trabulsi, Edouard J.   +10 more
core   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Castration-Resistant Lgr5+ Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration

Stem Cell Reports, 2015
The adult prostate possesses a significant regenerative capacity that is of great interest for understanding adult stem cell biology. We demonstrate that leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is expressed in a rare population
Bu-er Wang, Xi Wang, Jason E. Long, Jeff Eastham-Anderson, Ron Firestein, Melissa R. Junttila   +5 more
doaj   +1 more source

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. [PDF]

, 2020
BackgroundHyperpolarized (HP) 13C-pyruvate MRI is a stable-isotope molecular imaging modality that provides real-time assessment of the rate of metabolism through glycolytic pathways in human prostate cancer.
Aggarwal, Rahul, Bok, Robert A, Carvajal, Lucas, Chen, Hsin-Yu, Gordon, Jeremy W, Kurhanewicz, John, Larson, Peder EZ, Lee, Philip, Ohliger, Michael A, Slater, James B, Small, Eric J, van Criekinge, Mark, Vigneron, Daniel B, Zhu, Zi   +13 more
core  

Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer [PDF]

, 2017
is the first targeted alpha therapy for patients with castration resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach.
Carrió, Ignasi, De Vincentis, Giuseppe, Du, Yong, Fanti, Stefano, Ilhan, Harun, Lewington, Val, Mommsen, Caroline, Nitzsche, Egbert, Oyen, Wim, Sundram, Francis, Universitat Autònoma de Barcelona, Vogel, Wouter   +11 more
core   +4 more sources

Darolutamide For Castration-Resistant Prostate Cancer.

OncoTargets and therapy, 2019
The treatment landscape of advanced prostate cancer continues to evolve rapidly, with newer and more active drugs being used in earlier phases of the disease based on improved overall survival. After adoption of docetaxel for metastatic castration-sensitive disease, large trials with next-generation androgen receptor-signaling inhibitors (abiraterone ...
Bastos,Diogo A, Antonarakis,Emmanuel S
openaire   +3 more sources

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Queer configurations: The female divine, regional identity, and Queer‐religious belonging in South India

Feminist Anthropology, EarlyView.
Abstract This article explores how queerness and religion intersect in a unique enactment of Bathukamma, a flower festival honoring the female divine in Hyderabad, the capital of the South Indian state of Telangana. Drawing on theories of figuration, I analyze how local queer organizations celebrate the festival in a way that engages two distinctive ...
Stefan Binder
wiley   +1 more source

Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders [PDF]

, 2011
Biological and mechanistic relevance of intergenic disease-associated genetic loci (IDAGL) containing highly statistically significant disease-linked SNPs remains unknown. Here we present the experimental and clinical evidence revealing important role of
Anna Glinskii, Chang-Uk Lim, Denise Grant, Gennadi Glinsky, Ian Guest, Jun Ma, Ralph Buttyan, Shuang Ma, Stewart Sell   +8 more
core   +2 more sources