Results 111 to 120 of about 70,073 (274)

Post Hoc Subgroup Analysis of Clinical Outcomes in Patients With High‐Risk Metastatic Hormone‐Naïve Prostate Cancer: Results From a 3‐Year Interim Analysis of the J‐ROCK Study

The Prostate, Volume 86, Issue 5, Page 599-608, April 2026.
ABSTRACT Introduction In real‐world practice in Japan, standard treatment for metastatic hormone‐naïve prostate cancer (mHNPC) is androgen deprivation therapy (ADT), administered as monotherapy, combined androgen blockade (CAB), ADT plus androgen receptor pathway inhibitors (ARPIs), or ADT plus docetaxel.
Atsushi Mizokami, Rikiya Matsumoto, Hideaki Miyake, Hiroji Uemura, Hirotsugu Uemura, Satoru Kawakami, Kazuyoshi Nakamura, Shigekatsu Maekawa, Hiroaki Tsuchiya, Sachie Okazaki, Eri Adachi, Ryo Yano, Yohei Tajima, Kiyohide Fujimoto, Hideyasu Matsuyama   +14 more
wiley   +1 more source

PROCA11 early activation fuels prostate cancer neuroendocrine traits by regulating cell survival and migration

iScience
Summary: Tumor plasticity drives the emergence of castration-resistant and neuroendocrine prostate cancer following androgen-deprivation therapy (ADT).
Rocco Cipolla, Marc Gabriel, Ugo Szachnowski, Zhimin Wang, Martina Romani, Giorgia Ianese Regin, Micaela Piemontese, Virginie Firlej, Marina Pinskaya, Antonin Morillon   +9 more
doaj   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Cost-effectiveness analyses and cost analyses in castration-resistant prostate cancer: A systematic review.

PLoS ONE, 2018
BackgroundTreatment of metastatic prostate cancer is associated with high personal and economic burden. Recently, new treatment options for castration-resistant prostate cancer became available with promising survival advantages.
Thomas Grochtdreis, Hans-Helmut König, Alexander Dobruschkin, Gunhild von Amsberg, Judith Dams   +4 more
doaj   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Sipuleucel-T immunotherapy for castration-resistant prostate cancer.

New England Journal of Medicine, 2010
P. Kantoff, C. Higano, N. Shore, E. Berger, E. Small, D. Penson, C. Redfern, A. Ferrari, R. Dreicer, R. Sims, Yi Xu, M. Frohlich, P. Schellhammer   +12 more
semanticscholar   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy

EMBO Molecular Medicine
A critical knowledge gap in prostate cancer research is understanding whether castration-tolerant progenitor-like cells that reside in treatment-naïve tumors play a direct role in therapy resistance and tumor progression.
Manon Baurès, Anne-Sophie Vieira Aleixo, Emeline Pacreau, Aysis Koshy, Vanessa Friedrich, Marc Diedisheim, Martin Raigel, Yichao Hua, Charles Dariane, Florence Boutillon, Lukas Kenner, Jean-Christophe Marine, Gilles Laverny, Daniel Metzger, Florian Rambow, Jacques-Emmanuel Guidotti, Vincent Goffin   +16 more
doaj   +1 more source

Systematic Review of Genomic‐Based Risk Stratification in Localised Prostate Cancer Treatment Optimisation: Clinical Impact and Health Economic Evidence

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Several genomic risk stratification tests are available to predict the risk of metastasis and mortality for prostate cancer patients at the time of diagnosis. However, the evidence supporting the clinical utility of genomic risk stratification tools is fragmented, posing challenges in assessing their real‐world clinical impact and ...
Juntao Lyu, Fan He, Niall M. Corcoran, Gang Chen, Hadi Akbarzadeh Khorshidi   +4 more
wiley   +1 more source

Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial

Nature Medicine, 2022
T. Powles, Kobe Yuen, S. Gillessen, E. Kadel, D. Rathkopf, N. Matsubara, C. Drake, K. Fizazi, J. Piulats, P. Wysocki, G. Buchschacher, B. Alekseev, B. Mellado, B. Karaszewska, Jennifer F. Doss, Grozdana Rasuo, Asim Datye, S. Mariathasan, P. Williams, C. Sweeney   +19 more
semanticscholar   +1 more source