Results 141 to 150 of about 70,073 (274)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial.

The Lancet Oncology, 2014
Eugene D. Kwon, Charles G. Drake, H. Scher, K. Fizazi, A. Bossi, A. van den Eertwegh, M. Krainer, N. Houédé, Ricardo Santos, H. Mahammedi, S. Ng, M. Maio, Fabio A. Franke, S. Sundar, N. Agarwal, A. Bergman, T. Ciuleanu, E. Korbenfeld, L. Sengeløv, S. Hansen, C. Logothetis, T. M. Beer, M. McHenry, P. Gagnier, David Liu, W. Gerritsen   +25 more
semanticscholar   +1 more source

Death Anxiety During the Last Year of Life in Patients With Advanced Cancer: Longitudinal Results From the eQuiPe Study

Psycho-Oncology, Volume 35, Issue 3, March 2026.
ABSTRACT Background Death anxiety in patients with advanced cancer may increase during the last year of life due to increasing symptom burden and growing awareness of prognosis. Aims To examine the trajectory of death anxiety during the last year of life in patients with advanced cancer and its associated factors.
Moyke A. J. Versluis, Froukje E. de Vries, Yvette M. van der Linden, Hasan Alradhi, Marianne Kool, Jarmo C. B. Hunting, Hanneke W. M. van Laarhoven, Arnold Baars, Sander M. de Hosson, Wouter K. de Jong, Mathijs P. Hendriks, Marieke H. J. van den Beuken‐van Everdingen, Tineke J. Smilde, Magdolen Youssef‐El Soud, Marjolein H. Tilkema‐Tiebosch, Dirkje Sommeijer, Alexander de Graeff, Caroline Mandigers, Lia van Zuylen, Art Vreugdenhil, Annemieke van der Padt‐Pruijsten, Evelien J. M. Kuip, Lobke van Leeuwen‐Snoeks, Lonneke V. van de Poll‐Franse, Natasja J. H. Raijmakers   +24 more
wiley   +1 more source

Undifferentiated Castration-Resistant Prostate Cancer Successfully Treated With Carboplatin and Paclitaxel. [PDF]

Case Rep Urol
Sano M, Shimbo M, Ohgita S, Kanomata N, Hattori K, Endo F.   +5 more
europepmc   +1 more source

Cystoscopic ICG‐Guided Sentinel Lymph Node Dissection in Robotic Radical Prostatectomy: A Prospective Study

The Prostate, Volume 86, Issue 4, Page 481-492, March 2026.
ABSTRACT Background To evaluate the diagnostic accuracy, procedural feasibility, and clinical outcomes of a novel cystoscopic‐guided indocyanine green (ICG) injection technique followed by fluorescence‐guided sentinel lymph node dissection (SLND) during robotic‐assisted radical prostatectomy (RaRP), hereafter referred to as CysICG‐SLND.
Yi Hong Li, Yu Feng Chuang, Yen Chuan Ou, Yi Sheng Lin, Li Hua Huang, Wei Chun Weng, Chao Yu Hsu, Min Che Tung   +7 more
wiley   +1 more source

Erratum: [Corrigendum] Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer. [PDF]

Oncol Lett
Chen X, Yin L, Qiao G, Li Y, Li B, Bai Y, Feng F.   +6 more
europepmc   +1 more source

‘Sweating Blood’: Patients' Dirty Work in Informal Complaint Biographies

Sociology of Health &Illness, Volume 48, Issue 3, March 2026.
ABSTRACT Every day patients make informal complaints directly to care professionals. Although common in care encounters, the practice remains understudied. In this study, we focus on informal complaints through an analysis of interviews with 19 patients in Sweden, many living with chronic illness.
Jelmer Brüggemann, Lisa Guntram, Ann‐Charlotte Nedlund   +2 more
wiley   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source