Results 121 to 130 of about 219,417 (396)

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

Nature Communications, 2018
Expression of androgen receptor (AR) in prostate cancer (PCa) is heterogeneous but the functional significance of AR heterogeneity remains unclear. Screening ~200 castration-resistant PCa (CRPC) cores and whole-mount sections (from 89 patients) reveals 3
Qiuhui Li, Qu Deng, Hsueh-Ping Chao, Xin Liu, Yue Lu, K. Lin, Bigang Liu, G. Tang, Dingxiao Zhang, A. Tracz, Collene R. Jeter, K. Rycaj, Tammy Calhoun‐Davis, Jiaoti Huang, M. Rubin, H. Beltran, Jianjun Shen, G. Chatta, I. Puzanov, J. Mohler, Jianmin Wang, Ruizhe Zhao, J. Kirk, Xin Chen, D. Tang   +24 more
semanticscholar   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

COMPARATIVE EFFECTS OF DETOMIDINE AND XYLAZINE AS SEDATIVE AND ANALGESIC AGENTS IN SMALL RUMINANTS [PDF]

Pakistan Veterinary Journal, 2004
The study was carried out on 60 healthy rams and male goats presented for castration in the Surgery Clinics, Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore.
M. A. Khan, M. Ashraf, K. Pervez, H. B. Rashid, A. K. Mahmood and M. Chaudhry1
doaj  

Qualidade e composição química da carne de bovinos de corte inteiros ou castrados de diferentes grupos genéticos Charolês x Nelore Quality and composition of meat from entire or castrated beef cattle from different Charolais x Nellore genetic groups

Revista Brasileira de Zootecnia, 2001
Utilizaram-se 70 bovinos machos de três sistemas de acasalamento, puros Charolês (Ch) e Nelore (Ne), mestiços G1: 1/2 Ch + 1/2 Ne (1/2 Ch) e 1/2 Ne + 1/2 Ch (1/2 Ne) e mestiços G2: 3/4 Ch + 1/4 Ne (3/4 Ch) e 3/4 Ne + 1/4 Ch (3/4 Ne).
Fabiano Nunes Vaz, João Restle, Gelson Luis Dias Feijó, Ivan Luiz Brondani, Joilmaro Rodrigo Pereira Rosa, Angélica Pereira dos Santos   +5 more
doaj   +1 more source

A Passion for Castration: Characterizing Men Who Are Fascinated with Castration, but Have Not Been Castrated

The Journal of Sexual Medicine, 2008
ABSTRACT Introduction A number of men have extreme castration ideations. Many only fantasize about castration; others actualize their fantasies. Aims We wish to identify factors that distinguish those who merely fantasize about being ...
Lesley F. Roberts, Richard J. Wassersug, Michelle A. Brett, Thomas W. Johnson   +3 more
openaire   +3 more sources

Field experience with surgical castration with anaesthesia, analgesia, immunocastration and production of entire male pigs: performance, carcass traits and boar taint prevalence

Animal, 2015
Male piglets are castrated to reduce boar taint and also to reduce aggressive and sexual behaviour. However, the procedure as traditionally performed is painful and negatively affects performance.
M. Aluwé, F.A.M. Tuyttens, S. Millet
doaj  

Net requirements of energy, protein and macrominerals for weight gain of grazing beef cattle castrated at different ages, with and without supplementation

Revista Brasileira de Zootecnia, 2012
The objective of this experiment was to estimate the requirements of energy, protein and macrominerals of grazing crossbreds calves, in Brachiaria decumbens Stapf pasture, castrated at different ages, with and without supplementation.
Anilza Andréia da Rocha, Mário Fonseca Paulino, Henrique Jorge Fernandes, Lívia Vieira de Barros, Sidnei Antonio Lopes, Leandro Galon, Aline Gomes da Silva, Daniel Mageste de Almeida   +7 more
doaj   +1 more source

TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Astragalus polysaccharide (APS) supplement in beagle dogs after castration: Effects on the haematology and serum chemistry profiles, immune response, and oxidative stress status

Veterinary Medicine and Science, Volume 9, Issue 1, Page 98-110, January 2023., 2023
Astragalus polysaccharides improved immune response and antioxidant status in weanling beagle dogs Abstract Background Castration is one of the most common surgical procedures performed in dogs. However, based on increasing evidence, male animals experience significant pain after castration.
Jian‐Bo Luo, Lei Zhang, Min Fu, Yang Hong, Xin‐Yin Du, Guo‐Qiang Cheng, Jie‐Ying Xia, Han Dong   +7 more
wiley   +1 more source