Results 111 to 120 of about 219,205 (349)
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor [PDF]
, 2017 ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work
Bertoncini, Carlos W. +12 more
core +2 more sources
Restoration of Immune Surveillance in Prostate Cancer Prevention by Sulforaphane in Hi‐Myc Mice
Molecular Carcinogenesis, EarlyView.ABSTRACT Oral administration of broccoli constituent sulforaphane (SFN) prevents prostate cancer development in preclinical mouse models. However, the mechanism(s) underlying prostate cancer prevention by SFN are not fully understood. In this study, we used a human relevant mouse model (Hi‐Myc mice) to demonstrate restoration of immune surveillance by ...
Krishna B. Singh +3 more
wiley +1 more source
Managing Nonmetastatic Castration-resistant Prostate Cancer.
European Urology, 2019 CONTEXT Patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) have rising prostate-specific antigen (PSA) and castrate testosterone levels, with no radiological findings of metastatic disease on computed tomography and bone scan ...
J. Mateo +11 more
semanticscholar +1 more source
Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications. [PDF]
, 2019 The increasing number of patients with sequenced prostate cancer genomes enables us to study not only individual oncogenic mutations, but also capture the global burden of genomic alterations.
Bose, Rohit, Ryan, Matthew J
core +1 more source
Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]
, 2014 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W +5 more
core +2 more sources
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, EarlyView.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
, 2018 Crime-preventing neurointerventions (CPNs) are increasingly being used or advocated for crime prevention. There is increasing use of testosterone-lowering agents to prevent recidivism in sexual offenders, and strong political and scientific interest in ...
Birks, David, Douglas, Thomas
core
Emerging treatments for recurrent prostate cancer [PDF]
, 2015 Despite radical treatment, many men with prostate cancer will develop recurrence of their disease. In an exciting era of new therapies for prostate cancer in general, we focus on how these will specifically benefit those men with recurrent disease.
Hanna, Catherine, Jones, Robert J.
core +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Flowers can communicate reproductive status to pollinators through visual cues. In Saxifraga fortunei, pistils often changed from yellow to red after pollination, and hoverflies and honeybees preferentially visited flowers with yellow pistils. This pattern suggests that a post‐pollination color shift confined to the pistil can reduce revisits to ...
Kazuma Takizawa +2 more
wiley +1 more source
Animal welfare implications of surgical castration and its alternatives in pigs
Animal, 2009 This paper constitutes a review on the welfare aspects of piglet castration that considers the scientific literature published after 2004. Castrating during the neonatal period (1 to 3 days of age) is clearly painful.
E. von Borell +6 more
doaj +1 more source