Results 91 to 100 of about 86,006 (297)
Multi‐omics–driven precision medicine
iMeta, EarlyView.Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li +20 more
wiley +1 more source
Sheep farmers’ castration practices.
, 2022 Sheep farmers’ castration practices.
Demeke Haile Engidashet (12850750) +1 more
core +1 more source
Interdisciplinary Medicine, EarlyView.In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang +11 more
wiley +1 more source
Animal welfare implications of surgical castration and its alternatives in pigs
Animal, 2009 This paper constitutes a review on the welfare aspects of piglet castration that considers the scientific literature published after 2004. Castrating during the neonatal period (1 to 3 days of age) is clearly painful.
E. von Borell +6 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study evaluates the association between Notch1 and Notch3 genetic variations and serum protein levels in patients with benign prostatic hyperplasia and prostate cancer. While genetic variations showed no significant link to disease risk, serum protein levels were significantly lower in prostate cancer and metastatic groups compared to healthy ...
Emine Yagci +4 more
wiley +1 more source
AnimalsThe self-administration of meloxicam via medicated feed is a novel concept that could enable non-invasive, pre-emptive and long-term analgesia. Forty Bos taurus male calves were randomly allocated to four treatment groups: no castration (PC), surgical ...
Samantha Rudd +3 more
doaj +1 more source
Transcriptional regulators and regulatory pathways involved in prostate gland adaptation to a hypoandrogen environment [PDF]
Genetics and Molecular BiologyAnti-androgen therapies, including orchiectomy, are effective at promoting prostate cancer remission, but are followed by progression to the more aggressive castration-resistant prostate cancer (CRPC).
Umar Nishan +4 more
doaj +2 more sources
Abiraterone in the treatment of metastatic castration-resistant prostate cancer
, 2014 Elahe A Mostaghel Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Abstract: Androgen deprivation therapy remains the single most effective treatment for the initial therapy of advanced prostate cancer, but is ...
Mostaghel EA
core
Castration of the healthy bitch [PDF]
, 2010 In this work we have compiled results from various studies concerning medical conditions that may possibly be avoided by castration and the effects that may occur after castration of the healthy bitch. The work is a literature review but it also includes
Ullgren, Erika, Österberg, Jenny
core
, 2022 • Background: The very early castration of foals has not yet been studied despite the many positive effects observed in domestic carnivores. • Objectives: To compare the performance of castration at 3 days in foals and 18 months in yearlings and assess ...
Freret, Sandrine +2 more
core +1 more source