Results 81 to 90 of about 219,205 (349)

Genomics of lethal prostate cancer at diagnosis and castration resistance

Journal of Clinical Investigation, 2019
The genomics of primary prostate cancer differ from those of metastatic castration-resistant prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer biopsies from patients who developed mCRPC, also studying matching, same ...
J. Mateo, G. Seed, C. Bertan, P. Rescigno, D. Dolling, I. Figueiredo, S. Miranda, Daniel Nava Rodrigues, B. Gurel, M. Clarke, Mark Atkin, R. Chandler, C. Messina, S. Sumanasuriya, D. Bianchini, M. Barrero, Antonella Petermolo, Z. Zafeiriou, M. Fontes, R. Pérez-López, N. Tunariu, B. Fulton, Robert J. Jones, U. McGovern, C. Ralph, M. Varughese, O. Parikh, Suneil Jain, T. Elliott, S. Sandhu, N. Porta, E. Hall, W. Yuan, S. Carreira, J. D. de Bono   +34 more
semanticscholar   +1 more source

Mechanisms of enzalutamide resistance in castration‐resistant prostate cancer and therapeutic strategies to overcome it

British Journal of Pharmacology, 2020
Prostate cancer is the second most common malignancy in men and androgen deprivation therapy is the first‐line therapy. However, most cases will eventually develop castration‐resistant prostate cancer after androgen deprivation therapy treatment ...
Yuanyuan Wang, Jiyuan Chen, Zhengjie Wu, Weihong Ding, Shen Gao, Yuan Gao, Chuanliang Xu   +6 more
semanticscholar   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Development and Field Validation of Lidocaine-Loaded Castration Bands for Bovine Pain Mitigation

Animals, 2020
Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding.
James W. Saville, Joseph A. Ross, Tyler Trefz, Crystal Schatz, Heather Matheson-Bird, Brenda Ralston, Ori Granot, Karin Schmid, Richard Terry, Nicholas D. Allan, Jeremy E. Wulff, Merle Olson   +11 more
doaj   +1 more source

Effective Combinatorial Immunotherapy for Castration Resistant Prostate Cancer

Nature, 2017
A significant fraction of patients with advanced prostate cancer treated with androgen deprivation therapy experience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC).
Xin Lu, James W. Horner, E. Paul, Xiaoying Shang, P. Troncoso, Pingna Deng, Shan Jiang, Qing Chang, D. Spring, Padmanee Sharma, J. Zebala, D. Maeda, Y. A. Wang, Ronald A. DePinho   +13 more
semanticscholar   +1 more source

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

Animal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu, Yiwei Sun, Kun Cai, Pingli He, Gang Lin, Zengkai Qi, Hu Liu, Junshu Yan, Ning Ma   +8 more
wiley   +1 more source

‘Seeking Justice, Not Charity’. Medical Experiment Victims’ Struggle with Purposefully Inadequate Compensation

Eastern European Holocaust Studies
Germany’s initial Wiedergutmachung process did little good for survivors of Nazi medical experiments who struggled with uniquely devastating circumstances.
Weinberger Ruth Jolanda
doaj   +1 more source

Androgen and Oestrogen Affect the Expression of Long Non-Coding RNAs During Phallus Development in a Marsupial

Non-Coding RNA, 2018
There is increasing evidence that long non-coding RNAs (lncRNAs) are important for normal reproductive development, yet very few lncRNAs have been identified in phalluses so far.
Yu Chen, Yoko Kuroki, Geoff Shaw, Andrew J. Pask, Hongshi Yu, Atsushi Toyoda, Asao Fujiyama, Marilyn B. Renfree   +7 more
doaj   +1 more source

Comparative Plasma and Interstitial Fluid Pharmacokinetics of Meloxicam, Flunixin, and Ketoprofen in Neonatal Piglets

Frontiers in Veterinary Science, 2020
Piglet castration and tail-docking are routinely performed in the United States without analgesia. Pain medications, predominately non-steroidal anti-inflammatory drugs, are used in the EU/Canada to decrease pain associated with processing and improve ...
Emma Nixon, Glen W. Almond, Ronald E. Baynes, Kristen M. Messenger   +3 more
doaj   +1 more source