Results 101 to 110 of about 77,635 (307)
Transcriptional regulators and regulatory pathways involved in prostate gland adaptation to a hypoandrogen environment [PDF]
Genetics and Molecular BiologyAnti-androgen therapies, including orchiectomy, are effective at promoting prostate cancer remission, but are followed by progression to the more aggressive castration-resistant prostate cancer (CRPC).
Umar Nishan +4 more
doaj +2 more sources
Abiraterone in the treatment of metastatic castration-resistant prostate cancer
, 2014 Elahe A Mostaghel Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Abstract: Androgen deprivation therapy remains the single most effective treatment for the initial therapy of advanced prostate cancer, but is ...
Mostaghel EA
core
A Modern Metrical Baseline for Sexing Sheep Horn‐Cores
International Journal of Osteoarchaeology, EarlyView.ABSTRACT Sex determination is essential for reconstructing past livestock management, yet the limited skeletal sexual dimorphism of sheep hinders the identification of ewes, rams, and wethers in archaeological assemblages. Horn‐cores are the most sexually dimorphic element of the sheep skeleton, and here, we establish a new metrical baseline for ...
Julia Cussans +3 more
wiley +1 more source
La castration: une arme féminine?
, 2023 International audienceDénoncée à l'origine comme un exercice illégal par les médecins de l'époque moderne, la castration est le plus souvent liée au crime passionnel commis par les femmes au XIXe siècle.
Nagai, Ami
core +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Flowers can communicate reproductive status to pollinators through visual cues. In Saxifraga fortunei, pistils often changed from yellow to red after pollination, and hoverflies and honeybees preferentially visited flowers with yellow pistils. This pattern suggests that a post‐pollination color shift confined to the pistil can reduce revisits to ...
Kazuma Takizawa +2 more
wiley +1 more source
The Prostate, EarlyView.ABSTRACT Background Outcomes of metastatic castration‐resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic factors. We evaluated the prognostic value of serum neuron‐specific enolase (NSE) at baseline and early on‐treatment dynamics.
Ondřej Fiala +11 more
wiley +1 more source
State-Of-The-Art Treatment in Castration-Resistant Prostate Cancer
, 2014 Prostate cancer (PrCa) is the most common cancer type in men in developed countries. In the last few years, a dramatic change has occurred in the understanding of castration-resistant PrCa which has led to the development of new drugs that have an impact
Elena Castro, David Olmos, Nuria Romero
core
The Prostate, EarlyView.ABSTRACT Background The introduction of novel androgen receptor signaling inhibitors (ARSIs) has substantially transformed the systemic treatment landscape for non‐metastatic castration‐resistant prostate cancer (nmCRPC). Unfortunately, ARSI therapy is associated with considerable adverse events (AEs) and high medical costs.
Himawari Asanuma +18 more
wiley +1 more source
Castration Anxiety and Phobias
, 2002 Based on Freud's case study of “Little Hans,” the authors tested the hypothesis that men with phobias would score higher on castration anxiety than men without phobias. College men with either average or high scores on the Fears Scale of the MMPI–2 ( n =
Adrianne C. Lovelady +10 more
core +1 more source
Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death
Phytotherapy Research, EarlyView.ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi +6 more
wiley +1 more source