Results 121 to 130 of about 219,205 (349)

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Nature Medicine, 2022
V. Narayan, J. Barber-Rotenberg, In-Young Jung, S. Lacey, A. Rech, M. Davis, W. Hwang, P. Lal, E. Carpenter, S. Maude, G. Plesa, N. Vapiwala, A. Chew, Michael Moniak, R. Sebro, M. Farwell, A. Marshall, J. Gilmore, Lester Lledo, Karen Dengel, S. Church, Tyler D. Hether, Junnnan Xu, M. Gohil, Thomas H. Buckingham, S. Yee, V. Gonzalez, I. Kulikovskaya, Fang Chen, Lifeng Tian, Kyle Tien, W. Gladney, C. Nobles, H. Raymond, Diane Mary Elizabeth Holly Jonathan Samantha Sophia Juli Frazee Truran Veloso McConville Aguedelo Hower Ngo, D. Frazee, Mary Truran, E. Veloso, Holly McConville, Jonathan Aguedelo, S. Hower, Sophia Ngo, J. Jadlowsky, J. Melenhorst, A. Roche, J. Everett, Minnal Gupta, Farzana Nazimuddin, C. Bartoszek, Natalka Koterba, R. Reynolds, F. Ellington, Christopher C. Kloss, Jihyun Lee, Yangbing Zhao, J. Scholler, J. Riley, Christina Bailey, A. White, Briana M. Hudson, Pearl S Chang, M. Maus, B. Levine, E. Hexner, D. Siegel, F. Bushman, C. June, J. Fraietta, N. Haas   +68 more
semanticscholar   +1 more source

TheraP: a randomized phase 2 trial of 177Lu‐PSMA‐617 theranostic treatment vs cabazitaxel in progressive metastatic castration‐resistant prostate cancer (Clinical Trial Protocol ANZUP 1603)

BJU International, 2019
To assess the activity and safety of cabazitaxel chemotherapy vs that of treatment with 177Lu‐PSMA‐617, a novel radiolabelled small molecule that binds with high affinity to prostate‐specific membrane antigen (PSMA), in men with metastatic castration ...
M. Hofman, L. Emmett, J. Violet, Alison Y Zhang, N. Lawrence, M. Stockler, R. Francis, A. Iravani, S. Williams, A. Azad, A. Martin, M. McJannett, I. Davis   +12 more
semanticscholar   +1 more source

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target. [PDF]

, 2018
Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy.
Dorff, Tanya, Jolly, Mohit Kumar, Kulkarni, Prakash, Lau, Clayton, Orban, John, Salgia, Ravi, Weninger, Keith   +6 more
core   +3 more sources

Combining radiotherapy with CAR‐T cell therapy for solid tumors: Challenges, mechanisms, and future directions

Precision Radiation Oncology, EarlyView.
Radiotherapy enhances CAR‐Tcell therapy by increasing antigenicity, improving trafficking, and reshaping the tumor microenvironment. Despite its dual effects, including potential immune suppression, understanding these mechanisms enables the development of strategies to maximize synergy in solid tumors.
Leran Qiu, Xingyu Zhou, Jiao Xue, Xiaokang Zhang, Songbing Qin   +4 more
wiley   +1 more source

Self-Administration of Meloxicam via Medicated Molasses Lick Blocks May Improve Welfare of Castrated Calves

Animals
The self-administration of meloxicam via medicated feed is a novel concept that could enable non-invasive, pre-emptive and long-term analgesia. Forty Bos taurus male calves were randomly allocated to four treatment groups: no castration (PC), surgical ...
Samantha Rudd, Sabrina Lomax, Peter J. White, Dominique Van der Saag   +3 more
doaj   +1 more source

Transcriptional regulators and regulatory pathways involved in prostate gland adaptation to a hypoandrogen environment [PDF]

Genetics and Molecular Biology
Anti-androgen therapies, including orchiectomy, are effective at promoting prostate cancer remission, but are followed by progression to the more aggressive castration-resistant prostate cancer (CRPC).
Umar Nishan, Rafaela da Rosa-Ribeiro, Danilo Marchete Damas-Souza, Guilherme Oliveira Barbosa, Hernandes F. Carvalho   +4 more
doaj   +2 more sources

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source

Dark Triad Traits Affect the Perception of Emotions in Animal Calls. [PDF]

Int J Psychol
ABSTRACT Humans can recognize emotions from vocalisations of various animal species. Our study examined whether human psychological differences in dark personality traits (as measured by SD3) and musician experience affect the decoding of emotions in animal calls.
Maruščáková IL, Jakob L, Vydrová HV, Špinka M.   +3 more
europepmc   +2 more sources

Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. [PDF]

, 2020
BackgroundMetastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes.
Cadaneanu, Radu M, Freeman, Michael R, Garraway, Isla P, Grasso, Catherine S, Hodge, Jennelle, Kim, Minhyung, Knudsen, Beatrice S, Kwan, Lorna, Lewis, Michael S, Li, Xinmin, Liu, Sandy T, Miller, Eric T, Quist, Michael J, Yoon, Junhee, You, Sungyong   +14 more
core  

Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]

, 1989
Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla, A Mode, A Schleusener, AE Pegg, AJ Syms, B Katchen, CL Mendenhall, CW Bardin, D Kahn, DM Cohen, E Bresnidk, E Mezey, E Mezey, E Mezey, EM Higgins, ER Lax, F Neumann, J Simard, J Terblanche, JA Gustafsson, JA Gustafsson, JA McGowan, JH Clark, JM Kissane, JP Blondeau, KE Crow, LE Porter, M Kayfman, M Sarff, MF Zuretti, OH Lowry, PK Eagon, PK Eagon, PK Eagon, R Neri, W Welshons, WJ King   +36 more
core   +1 more source