Results 41 to 50 of about 2,510,669 (328)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genomic adaptation to small population size and saltwater consumption in the critically endangered Cat Ba langur

Nature Communications
Many mammal species have declining populations, but the consequences of small population size on the genomic makeup of species remain largely unknown.
Liye Zhang, Neahga Leonard, Rick Passaro, Mai Sy Luan, Pham Van Tuyen, Le Thi Ngoc Han, Nguyen Huy Cam, Larry Vogelnest, Michael Lynch, Amanda E. Fine, Nguyen Thi Thanh Nga, Nguyen Van Long, Benjamin M. Rawson, Alison Behie, Truong Van Nguyen, Minh D. Le, Tilo Nadler, Lutz Walter, Tomas Marques-Bonet, Michael Hofreiter, Ming Li, Zhijin Liu, Christian Roos   +22 more
doaj   +1 more source

Fast and Lightweight Object Detection Network: Detection and Recognition on Resource Constrained Devices

IEEE Access, 2018
The intrinsic ability of humans to rapidly detect, differentiate, and classify objects allows us to make quick decisions in regards to what we see. Several appliances can make use of fast and lightweight automated object detection for images or videos ...
Bernardo Augusto Godinho de Oliveira, Flavia Magalhaes Freitas Ferreira, Carlos Augusto Paiva da Silva Martins   +2 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Cat Hobaiter [PDF]

Current Biology, 2020
Interview with Cat Hobaiter, who studies the evolution of communication, cognition and social behaviour in apes at the University of St Andrews and through field studies in the Budongo Forest in Uganda.
openaire   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Behavioral differences among domestic cats in the response to cat-attracting plants and their volatile compounds reveal a potential distinct mechanism of action for actinidine

BMC Biology, 2022
Background It has been known for centuries that cats respond euphorically to Nepeta cataria (catnip). Recently, we have shown that Lonicera tatarica (Tatarian honeysuckle), Actinidia polygama (silver vine), and Valeriana officinalis (valerian) can also ...
Sebastiaan Bol, Adrian Scaffidi, Evelien M. Bunnik, Gavin R. Flematti   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Effects of a Microbial Enzyme Mixture on Macronutrient Hydrolysis in a Static Simulation of Oro-Gastric Digestion That Models Human Digestive Senescence

Foods
Observational studies have shown that human digestive function declines naturally with age. Oral enzyme supplementation is a candidate strategy to enhance macronutrient digestion in older adults.
Sean M. Garvey, Erin N. Madden, Yunyao Qu, Caroline H. Best, Kelly M. Tinker   +4 more
doaj   +1 more source

Bereaved Mothers and Masculine Queens: The Political Use of Maternal Grief in 1–2 Kings

Open Theology, 2020
Recent research demonstrates that maternal grief functions paradigmatically to epitomize despair and sorrow in the Hebrew Bible. These literary uses of maternal grief reinforce the stereotype of womanhood, defined by devotion to children and anguish at ...
Quine Cat
doaj   +1 more source