Results 81 to 90 of about 2,510,669 (328)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Biocentrism and Marxism: Bloch’s Concept of Life and the "Spirit of Utopia"
Praktyka Teoretyczna, 2020 This article argues that Ernst Bloch’s (1885-1977) early philosophical development was profoundly influenced by a biocentric perspective that dominated European culture in the decades around the turn of the twentieth century.
Cat Moir
doaj +1 more source
Australian Government measures to counter violent extremism: a quick guide [PDF]
This guide identifies what is meant by violent extremism and outlines relevant counter-measures pursued by the Australian Government to date. Introduction Countering violent extremism was highlighted as an ‘essential element’ of efforts to deal with ...
Cat Barker
core
Completions, branched covers, Artin groups and singularity theory
, 2011 We study the curvature of metric spaces and branched covers of Riemannian manifolds, with applications in topology and algebraic geometry. Here curvature bounds are expressed in terms of the CAT(k) inequality. We prove a general CAT(k) extension theorem,
Allcock, Daniel
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
The people smugglers’ business model [PDF]
While discussions continue on how best to go about breaking the people smugglers’ business model, those participating in the debate have not publicly articulated the business model to which they refer. This has significant policy implications, given that
Cat Barker
core
Cation-Responsive and Photocleavable Hydrogels from Noncanonical Amphiphilic DNA Nanostructures [PDF]
, 2022 Giacomo Fabrini +4 more
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Knowledge Management as Enterprise
The Australian Journal of Indigenous Education, 2007 Indigenous people have been for a long time deprived of financial benefit from their knowledge. Campaigns around the stolen wages and the “Pay the Rent” campaign highlight this.
Cat Kutay
doaj +1 more source
Counter-terrorism and national security legislation reviews: a comparative overview [PDF]
This paper outlines the key reviews of Australia\u27s counter-terrorism and national security legislation, followed by a more detailed comparison of the recommendations of the Independent National Security Legislation Monitor and Council of Australian ...
Cat Barker
core