Results 21 to 30 of about 265,603 (330)

Lysine Catabolism Reprograms Tumour Immunity through Histone Crotonylation

Nature, 2023
Cancer cells rewire metabolism to favour the generation of specialized metabolites that support tumour growth and reshape the tumour microenvironment^ 1 , 2 .
Huairui Yuan, Xujia Wu, Qiulian Wu, Adam Chatoff, Emily Megill, Jinjun Gao, Tengfei Huang, Tingting Duan, Kailin Yang, Chunyu Jin, Fa-Nen Yuan, Shuai Wang, Linjie Zhao, P. Zinn, K. Abdullah, Ying-Ming Zhao, N. Snyder, Jeremy N. Rich   +17 more
semanticscholar   +1 more source

Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass

Frontiers in Cell and Developmental Biology, 2021
Cachexia is a complex wasting syndrome that overwhelmingly affects the majority of late-stage cancer patients. Additionally, there are currently no efficacious therapeutic agents to treat the muscle atrophy induced by the cancer.
Alex R. Straughn, Natia Q. Kelm, Sham S. Kakar, Sham S. Kakar   +3 more
doaj   +1 more source

Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria [PDF]

, 2021
Catabolism of sulfoquinovose (SQ, 6-deoxy-6-sulfoglucose), the ubiquitous sulfosugar produced by photosynthetic organisms, is an important component of the biogeochemical carbon and sulfur cycles.
Runyao, Mao, Michael, Jarva, Spencer, Williams, Gideon, Davies, Ruwan, Epa, David, Ascher, Janice, Mui, Eleanor, Saunders, Ethan, Goddard-Borger, Alexander, Snow, Marija, Petricevic, Yunyang, Zhang, Malcolm, McConville, Douglas, Pires, Nichollas, Scott, Bruna, da Silva, Mahima, Sharma, James, Lingford   +17 more
core   +2 more sources

Effects of Absorption Kinetics on the Catabolism of Melatonin Released from CAP-Coated Mesoporous Silica Drug Delivery Vehicles

Pharmaceutics, 2021
Melatonin (MLT) is a pineal hormone involved in the regulation of the sleep/wake cycle. The efficacy of exogenous MLT for the treatment of circadian and sleep disorders is variable due to a strong liver metabolism effect.
Irene Moroni, Alfonso E. Garcia-Bennett
doaj   +1 more source

Heme Scavenging and Delivery: The Role of Human Serum Albumin

Biomolecules, 2023
Heme is the reactive center of several metal-based proteins that are involved in multiple biological processes. However, free heme, defined as the labile heme pool, has toxic properties that are derived from its hydrophobic nature and the Fe-atom ...
Giovanna De Simone, Romualdo Varricchio, Tommaso Francesco Ruberto, Alessandra di Masi, Paolo Ascenzi   +4 more
doaj   +1 more source

The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology

International Journal of Molecular Sciences, 2022
Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino acids widely studied for their crucial role in the regulation of protein synthesis mainly through the activation of the mTOR signaling pathway and their emerging ...
A. Dimou, V. Tsimihodimos, E. Bairaktari
semanticscholar   +1 more source

Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism

Nature Metabolism, 2022
Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and hyperlipidemia through modulating the gut microbiota in obese mice.
Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huan-Qin Dai, Kai Wang, Li Bao, Han-Tian Li, Wenzhao Wang, Shuang-Jiang Liu, Hong-Wei Liu   +10 more
semanticscholar   +1 more source

Perioperative catabolism [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2015
This article reviews the pathophysiology, clinical relevance, and therapy of the catabolic response to surgical stress.The key clinical features of perioperative catabolism are hyperglycemia and loss of body protein, both metabolic consequences of impaired insulin function.
Thomas, Schricker, Ralph, Lattermann
openaire   +2 more sources

Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which the prognosis is determined by liver fibrosis.
P. Luukkonen, I. Sakuma, R. C. Gaspar, M. Mooring, Ali R. Nasiri, Mario Kahn, Xian-Man Zhang, Dong-Yan Zhang, H. Sammalkorpi, Anne K. Penttilä, M. Orho-Melander, J. Arola, A. Juuti, Xu-Chen Zhang, Dean Yimlamai, H. Yki-Järvinen, K. Petersen, G. Shulman   +17 more
semanticscholar   +1 more source

TArget-Responsive Subcellular Catabolism Analysis for Early-stage Antibody-Drug Conjugates Screening and Assessment [PDF]

, 2020
Key events including antibody-antigen affinity, ADC internalization, trafficking and lysosomal proteolysis-mediated payload release combinatorially determine the therapeutic efficacy and safety for ADCs.
Guangji, Wang, Jiali, Liu, Xiaofang, Zhang, Fang, Zhou, Yazhong, Liu, Jingwei, Zhang, Hua, Sang, Hui, Ye   +7 more
core   +1 more source