Branched-chain amino acids catabolism and cancer progression: focus on therapeutic interventions
Frontiers in Oncology, 2023 Branched-chain amino acids (BCAAs), including valine, leucine, and isoleucine, are crucial amino acids with significant implications in tumorigenesis across various human malignancies.
Er Xu, Bangju Ji, Ketao Jin, Yefeng Chen
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European Journal of Histochemistry, 2022 HMGB1 is a highly conserved nuclear protein that is rapidly released into the extracellular environment during infection or tissue damage. In osteoarthritis, HMGB1 acts as a pro-inflammatory cytokine inducing a positive feedback loop for synovial ...
Yan Yan Li +4 more
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Ferroptosis Inhibition by Lysosome-Dependent Catabolism of Extracellular Protein
Cell Chemical Biology, 2022 SUMMARY Cancer cells must ensure a steady supply of nutrients to enable proliferation and evade cell death. Depriving cancer cells of the amino acid cystine can trigger the non-apoptotic cell death process of ferroptosis.
David A. Armenta +8 more
semanticscholar +1 more source
Cryo‐EM structure of fission yeast tetrameric α‐mannosidase Ams1
FEBS Open Bio, 2020 Fungal α‐mannosidase Ams1 and its mammalian homolog MAN2C1 hydrolyze terminal α‐linked mannoses in free oligosaccharides released from misfolded glycoproteins or lipid‐linked oligosaccharide donors.
Jianxiu Zhang +3 more
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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.
Cell Stem Cell, 2022 Hematopoietic stem cells (HSCs) adapt their metabolism to maintenance and proliferation; however, the mechanism remains incompletely understood. Here, we demonstrated that homeostatic HSCs exhibited high amino acid (AA) catabolism to reduce cellular AA ...
Changzheng Li +12 more
semanticscholar +1 more source
Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation
Frontiers in Physiology, 2020 Patients with cancer cachexia (CCX) suffer from muscle wasting, which is often but not always accompanied by selective loss of myosin. Here we examined the effects of CCX on muscle mass and myosin heavy chain (MyHC) expression in denervated (DEN) muscles,
Takashi Yamada +4 more
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Unraveling the 17β-Estradiol Degradation Pathway in Novosphingobium tardaugens NBRC 16725
Frontiers in Microbiology, 2020 We have analyzed the catabolism of estrogens in Novosphingobium tardaugens NBRC 16725, which is able to use endocrine disruptors such as 17β-estradiol, estrone, and estriol as sole carbon and energy sources.
Juan Ibero +3 more
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Role of Parathyroid Hormone and Parathyroid Hormone-Related Protein in Protein-Energy Malnutrition
Frontiers in Bioscience-Landmark, 2023 Parathyroid hormone (PTH) is an endocrine peptide found exclusively in the parathyroid glands, whereas parathyroid hormone-related protein (PTHrP) is expressed in a wide range of tissues and organs and exerts endocrine, paracrine, and autocrine actions ...
Praopilad Srisuwarn +1 more
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Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803 [PDF]
, 2007 Schriek S, Rückert C, Staiger D, Pistorius EK, Michel K-P. Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis ...
Klaus-Peter Michel +14 more
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, 2021 **Background:** Diet and nutrition applications (apps) have become more readily accessible as smartphone ownership increases. These apps have the potential to improve nutritional outcomes, but it remains unclear whether they are effective in patients ...
Tandon, Puneeta +3 more
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