Results 61 to 70 of about 184,861 (296)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Functional requirements for bibliographic records: global experiences and future visions for library catalogs available via the Internet. 1

Cybrarians Journal, 2009
Libraries and the information services they provide on the Internet face a set of challenges imposed by rapid developments in information technology and remote communications.
Mohamed Helmy
doaj   +1 more source

SQUAB—I: The First Release of Strange QUasar Candidates With ABnormal Astrometric Characteristics From Gaia EDR3 and SDSS

Frontiers in Astronomy and Space Sciences, 2022
Given their extremely large distances and small apparent sizes, quasars are generally considered as objects with near-zero parallax and proper motion.
Qi-Qi Wu, Qi-Qi Wu, Shi-Long Liao, Shi-Long Liao, Xiang Ji, Xiang Ji, Zhao-Xiang Qi, Zhao-Xiang Qi, Zhen-Ya Zheng, Zhen-Ya Zheng, Ru-Qiu Lin, Ru-Qiu Lin, Ying-Kang Zhang, Ying-Kang Zhang, Tao An, Tao An   +15 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

DESCQA: An Automated Validation Framework for Synthetic Sky Catalogs [PDF]

, 2017
The use of high-quality simulated sky catalogs is essential for the success of cosmological surveys. The catalogs have diverse applications, such as investigating signatures of fundamental physics in cosmological observables, understanding the effect of ...
Yao-Yuan Mao, E. Kovacs, K. Heitmann, T. Uram, A. Benson, D. Campbell, S. Cora, J. DeRose, T. Matteo, S. Habib, A. Hearin, J. Kalmbach, K. Krughoff, F. Lanusse, Z. Luki'c, R. Mandelbaum, J. Newman, N. Padilla, E. Paillas, A. Pope, P. Ricker, A. Ruiz, Ananth Tenneti, C. Vega-Mart'inez, Risa Wechsler, R. Zhou, Y. Zu, for the Lsst Collaboration   +27 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Editoriales universitarias y mercado. Tendencias de comercialización en feria = University publishers and market: fair marketing trends

Información, Cultura y Sociedad, 2021
Este artículo indaga cómo se desenvuelven en el mercado editorial los sellos de universidades nacionales de gestión pública, tomando como eje de análisis la comercialización de libros a través de un stand colectivo de la Red de Editoriales de ...
Ivana Mihal
doaj   +1 more source

DARK MATTER SEARCHES IN THE GAMMA-RAY EXTRAGALACTIC BACKGROUND VIA CROSS-CORRELATIONS WITH GALAXY CATALOGS [PDF]

, 2015
We compare the measured angular cross-correlation between the Fermi-Large Area Telescope γ-ray sky and catalogs of extragalactic objects with the expected signal induced by weakly interacting massive particle (WIMP) dark matter (DM).
A. Cuoco, J. Xia, M. Regis, E. Branchini, N. Fornengo, M. Viel   +5 more
semanticscholar   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Rate‐Dependent Incompleteness of Earthquake Catalogs

, 2016
Important information about the earthquake generation process can be gained from instrumental earthquake catalogs, but this requires complete recordings to avoid biased results. The local completeness magnitude Mc is known to depend on general conditions
S. Hainzl
semanticscholar   +1 more source