Results 111 to 120 of about 856,604 (396)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Mirror symmetry breaking with limited enantioselective autocatalysis and temperature gradients: a stability survey

, 2012
We analyze limited enantioselective (LES) autocatalysis in a temperature gradient and with internal flow/recycling of hot and cold material. Microreversibility forbids broken mirror symmetry for LES in the presence of a temperature gradient alone.
Blanco, Celia, Crusats, Joaquim, El-Hachemi, Zoubir, Hochberg, David, Moyano, Albert, Ribó, Josep M.   +5 more
core   +1 more source

Tuning graphitic oxide for initiator- and metal-free aerobic epoxidation of linear alkenes

Nature Communications, 2016
Graphitic oxide is readily produced by the oxidation of graphite. Here the authors show that the amount and nature of the oxidant can be used to tune the properties of graphitic oxide, and furthermore report a carbocatalyst for alkene epoxidation without
Samuel Pattisson, Ewa Nowicka, Upendra N. Gupta, Greg Shaw, Robert L. Jenkins, David J. Morgan, David W. Knight, Graham J. Hutchings   +7 more
doaj   +1 more source

Nitrogen Doped Carbon Nanotubes and Nanofibers for Green Hydrogen Production: Similarities in the Nature of Nitrogen Species, Metal–Nitrogen Interaction, and Catalytic Properties

Energies, 2019
The effect of nitrogen doped bamboo-like carbon nanotubes (N−CNTs) on the properties of supported platinum (0.2 and 1 wt %) catalysts in formic acid decomposition for hydrogen production was studied.
Olga Podyacheva, Alexander Lisitsyn, Lidiya Kibis, Andrei Boronin, Olga Stonkus, Vladimir Zaikovskii, Arina Suboch, Vladimir Sobolev, Valentin Parmon   +8 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Biofilm-based biocatalysis for β-cyclodextrin production by the surface-display of β-cyclodextrin glycosyltransferase in Bacillus subtilis

Scientific Reports
β-cyclodextrin (β-CD) is an important cyclic oligosaccharide, which is widely applicated in foods, environmental protection, and cosmetics, primarily prepared from enzymatic synthesis in traditional industry.
Dan Wang, Sinan Wang, Wenjun Sun, Tianpeng Chen, Caice Liang, Pengpeng Yang, Qingguo Liu, Chunguang Zhao, Yong Chen   +8 more
doaj   +1 more source

Magnetic catalysis and inverse magnetic catalysis in QCD [PDF]

arXiv, 2015
We investigate the effects of strong magnetic fields on the QCD phase structure at vanishing density by solving the gluon and quark gap equations, and by studying the dynamics of the quark scattering with the four-fermi coupling. The chiral crossover temperature as well as the chiral condensate are computed.
arxiv  

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Inverse magnetic catalysis in field theory and gauge-gravity duality

, 2012
We investigate the surface of the chiral phase transition in the three-dimensional parameter space of temperature, baryon chemical potential and magnetic field in two different approaches, the field-theoretical Nambu-Jona-Lasinio (NJL) model and the ...
A. Kurkela, A. Rebhan, A. Rebhan, A. Rebhan, A. Rebhan, A.M. Clogston, B. Chatterjee, B.S. Chandrasekhar, C.V. Johnson, D. Ebert, D. Lai, D. Nickel, D.E. Kharzeev, D.E. Kharzeev, D.P. Menezes, E. Nakano, E. Witten, E.G. Thompson, E.V. Gorbar, E.V. Gorbar, E.V. Gorbar, F. Preis, F. Preis, G. Lifschytz, G. Policastro, G.N. Ferrari, G.S. Bali, I.E. Frolov, J. Bardeen, J. Bardeen, J. Erdmenger, J. Erdmenger, J.K. Boomsma, J.M. Maldacena, J.O. Andersen, J.S. Schwinger, K. Fukushima, K. Fukushima, K. Fukushima, K.G. Klimenko, K.G. Klimenko, L. McLerran, M. Brigante, M. Buballa, M. D’Elia, M.A. Metlitski, M.G. Alford, M.G. Alford, M.K. Volkov, N. Callebaut, N. Horigome, O. Aharony, O. Bergman, O. Bergman, O. Bergman, P. Kovtun, R.C. Duncan, S. Bolognesi, S.S. Avancini, Sh. Fayazbakhsh, Sh. Fayazbakhsh, T. Hatsuda, T. Inagaki, T. Sakai, T. Sakai, V. Schön, V. Skokov, V.G. Filev, V.G. Filev, V.G. Filev, V.P. Gusynin, V.P. Gusynin, V.P. Gusynin, V.P. Gusynin, V.P. Gusynin, Y. Aoki, Y. Aoki, Y. Nambu, Y. Nambu   +78 more
core   +2 more sources