Results 61 to 70 of about 222,894 (267)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Catalysis Science in China: From Traditional Techniques to Modern Innovations

Natural Sciences
As a recipient and learner of modern sciences, China has made significant strides in catalysis research and application over the past century and a half.
Zhiliang Li, Xianbiao Fu
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tuning graphitic oxide for initiator- and metal-free aerobic epoxidation of linear alkenes

Nature Communications, 2016
Graphitic oxide is readily produced by the oxidation of graphite. Here the authors show that the amount and nature of the oxidant can be used to tune the properties of graphitic oxide, and furthermore report a carbocatalyst for alkene epoxidation without
Samuel Pattisson, Ewa Nowicka, Upendra N. Gupta, Greg Shaw, Robert L. Jenkins, David J. Morgan, David W. Knight, Graham J. Hutchings   +7 more
doaj   +1 more source

Structural Changes of Mo/ZSM-5 Catalysts During the Methane Dehydroaromatization

Eurasian Chemico-Technological Journal, 2010
The structure changes of Mo/ZSM-5 catalysts with different Mo content (2 and 10 wt. % Mo) and Si/Al atomic ratio (17, 30 and 45) during the methane dehydroaromatization have been investigated by X-ray powder diffractometry, N2 adsorption and ...
Z. R. Ismagilov, E. V. Matus, I. Z. Ismagilov, M. A. Kerzhentsev, V. I. Zaikovskii, K. D. Dosumov, A. G. Mustafin   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Perspectives on the Catalytic Processes for the Deep Valorization of Carbohydrates into Fuels and Chemicals

Molecules
The global depletion of fossil resources, combined with accelerating climate change and environmental concerns, is driving intensive research into alternative, sustainable sources of energy and raw materials.
Aigul T. Zamanbekova, Alima K. Zharmagambetova, Assemgul S. Auyezkhanova, Eldar T. Talgatov, Aigul I. Jumekeyeva, Sandugash N. Akhmetova, Alima M. Kenzheyeva   +6 more
doaj   +1 more source

Methane dry reforming over Ni catalysts supported on Ce–Zr oxides prepared by a route involving supercritical fluids

Open Chemistry, 2017
Ce0.5Zr0.5O2 mixed oxides were prepared in a flow reactor in supercritical isopropanol with acetylacetone as a complexing agent. Variation of the nature of the Zr salt and the temperature of synthesis affected the phase composition, morphology and ...
Smirnova Marina Yu., Bobin Aleksei S., Pavlova Svetlana N., Ishchenko Arcady V., Selivanova Aleksandra V., Kaichev Vasilii V., Cherepanova Svetlana V., Krieger Tamara A., Arapova Marina V., Roger Anne-Cecile, Adamski Andrzej, Sadykov Vladislav A.   +11 more
doaj   +1 more source