Results 71 to 80 of about 398,278 (315)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Lewis Acidity in Cracking and Polymerization Catalysis

, 2019
The aim of this PhD thesis was to provide insight into the nature and variety of Lewis acidity in solid acid catalysts and to clarify the role of Lewis acid sites in fluid catalytic cracking (FCC) and metallocene-based olefin polymerization catalysis ...
Sub Inorganic Chemistry and Catalysis, Inorganic Chemistry and Catalysis, Velthoen, Marjolein Elise Zoë   +2 more
core  

The effect of iron catalyzed graphitization on the textural properties of carbonized cellulose: Magnetically separable graphitic carbon bodies for catalysis and remediation [PDF]

, 2016
Whereas pyrolysis of pristine microcrystalline cellulose spheres yields nonporous amorphous carbon bodies, pyrolysis of microcrystalline cellulose spheres loaded with iron salts leads to the formation of magnetically separable mesoporous graphitic carbon
Hoekstra, J, Geus, John W., Geus, JW, Beale, Andrew M., Hoekstra, Jacco, Van De Kleut, Dirk, Koelewijn, Jacobus M., van de Kleut, D, Sub Organic Chemistry and Catalysis, Beale, AM, Sub Inorganic Chemistry and Catalysis, Inorganic Chemistry and Catalysis, Soulimani, F, Organic Chemistry and Catalysis, Versluijs-Helder, M, Jenneskens, LW, Soulimani, Fouad, Jenneskens, Leonardus W., Koelewijn, JM, Versluijs-Helder, Marjan   +19 more
core   +1 more source

Computational Catalysis—Trends and Outlook

, 2021
Computational catalysis has been one of the most dynamic research fields over the last decade, and it now represents a critical tool for the analysis of chemical mechanisms and active sites [...
Christoffer Heath Turner
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Large Ferrierite Crystals as Models for Catalyst Deactivation during Skeletal Isomerisation of Oleic Acid: Evidence for Pore Mouth Catalysis

, 2016
Large zeolite crystals of ferrierite have been used to study the deactivation, at the single particle level, of the alkyl isomerisation catalysis of oleic acid and elaidic acid by a combination of visible micro-spectroscopy and fluorescence microscopy ...
Inorganic Chemistry and Catalysis, Sub Inorganic Chemistry and Catalysis, Wiedemann, Sophie C. C., Weitkamp, Jens, Kaerger, Joerg, Ristanovic, Zoran, Marthala, V. R. Reddy, Wels, Bas, Weckhuysen, Bert M., Bruijnincx, Pieter C. A., Whiting, Gareth T.   +10 more
core   +1 more source

Evaluation of particle size effect on two-phase flow distribution in a hydrotreatment reactor guard bed using particle-resolved CFD simulations

Chimica Techno Acta
Trickle bed reactors with solid catalyst pellets are important and widely used large-scale apparatuses in the chemical and oil refining industries. In order to reduce the effects of poisons on the catalyst bed and to extend the catalyst loading service ...
Ivan A. Mik, Oleg P. Klenov, Ivan S. Golubev, Pavel P. Dik, Sergey I. Reshetnikov, Alexandr S. Noskov   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

New frontiers in X-ray spectroscopy in heterogeneous catalysis: Using Fe/ZSM-5 as test-system

, 2005
We have applied a number of novel X-ray spectroscopic tools to Fe/ZSM-5 systems. Fe/ZSM-5 can be considered as an ideal test-system for the characterization techniques in heterogeneous catalysis.
Inorganic Chemistry and Catalysis 1, Koningsberger, D.C., de Groot, F.M.F., Katalyse en spectroscopie, Weckhuysen, B.M., Heijboer, W.M., Dep Scheikunde   +6 more
core   +1 more source