Results 71 to 80 of about 464,312 (316)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Progress in Reaction-Controlled Phase-Transfer Catalysis
Reaction-controlled phase-transfer catalysis is a new catalytic system This catalytic system is homogeneous during the reaction After the reaction the catalyst becomes insoluble solid and precipitates from the reaction medium. so that the catalyst can be
Li Jun, Gao Shuang, Xi Zuwei
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Non-linear Effects in Asymmetric Catalysis: Whys and Wherefores [PDF]
It is argued that the titled non-linear effects (NLE) may arise whenever the order of the reaction in the chiral catalyst in greater than 1. In a fundamental departure from previous approaches, this is mathematically elaborated for the second order case.
Sosale Chandrasekhar
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Nanoscale thermodynamic aspects of plasma catalysis
: Plasma catalysis continues to gain increasing scientific interest, both in established fields like toxic waste abatement and emerging fields like greenhouse gas conversion into value-added chemicals.
Ostrikov, Kostya (Ken) +3 more
core +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
The Pursuit of Effective Catalysis for C-C and C-N Cross-Coupling under Mild Conditions
Homogeneous transition metal-catalysis has had a great impact on the synthesis of organic molecules in recent years. The selective mono-arylation of small molecules, a class of reactions predominantly achieved via transition metal-catalyzed cross ...
MacQueen, Preston
core
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Magnesium aluminophosphate molecular sieves are promising materials for the development of catalysts for the hydroisomerization of higher n-paraffins in fuels and oils.
Dmitry Serebrennikov +7 more
doaj +1 more source

