Results 51 to 60 of about 238,554 (268)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Monitoring the Hydrothermal Crystallization of Ga/ZSM-5 Using Sorption and other Conventional Techniques

Adsorption Science & Technology, 1999
Sorption techniques have been employed for monitoring progress in the hydrothermal crystallization of synthetic MFI-type gallosilicate from a (TEBA) 2 O–Na 2 O–Ga 2 O 3 –SiO 2 –H 2 O system at 453 K.
S.V. Awate, P.N. Joshi, T.H. Kim, K.I. Kim, V.P. Shiralkar   +4 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, Volume 20, Issue 6, Page 1392-1397, June 2026.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Variation patterns of physical property parameters for pipeline transportation of impurity-containing NH3

You-qi chuyun
ObjectivePipeline transportation is one of the most economical and safest methods for the large-scale transport of ammonia (NH3), which is recognized as a clean energy source.
Pengbo YIN, Bo WANG, Zhenchao LI, Chaofei NIE, Jiaqing LI, Xiucan JIA, Lin TENG, Lilong JIANG   +7 more
doaj   +1 more source

Investigation of the catalytic performance and coke formation of nanocrystalline Ni/SrO-Al2O3 catalyst in dry reforming of methane [PDF]

Hydrogen, Fuel Cell & Energy Storage, 2017
In this study, nickel catalysts supported on mesoporous nanocrystalline gamma alumina promoted by various strontium contents were prepared by the impregnation method and employed in dry reforming of methane (DRM).
Elaheh Amir, Mehran Rezaei, Fereshteh Meshkani   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Whole life sustainability

Construction Economics and Building, 2014
Ian Ellingham and William Fawcett, RIBA Publishing, London, 2013, 160 p., ISBN 978 1 85946 450 2, AUD 56.84, GBP 30.84, USD 51 ...
PC Thomas
doaj   +3 more sources

A review of research progress on the corrosion behavior and relevant protection techniques of liquid ammonia under complex transmission environments

You-qi chuyun
[Objective] Against the backdrop of the “dual carbon” initiative, ammonia has emerged as a carbon-free and hydrogen-rich energy carrier with exceptional growth potential.
LI Jiaqing, FENG Zhiyu, LIANG Huilong, YIN Pengbo, TENG Lin, CHEN Chongqi, LUO Yu, JIANG Lilong   +7 more
doaj   +1 more source