Results 201 to 210 of about 4,561,775 (254)

Myosin Catalytic Domain Flexibility in MgADP

Biochemistry, 1994
Conventional EPR studies of muscle fibers labeled with a novel alpha-iodoketo spin label at Cys-707 of the myosin head revealed substantial internal domain reorganization on the addition of ADP to rigor fibers. The spin probes that are well-ordered in the rigor state become disordered and form two distinct populations.
D, Raucher, C P, Sár, K, Hideg, P G, Fajer   +3 more
openaire   +2 more sources

Expression and Crystallization of HDAC6 Tandem Catalytic Domains

2022
Histone deacetylase 6 (HDAC6) is an atypical lysine deacetylase with tandem catalytic domains and an ubiquitin-binding zinc finger domain. HDAC6 is involved in various biological processes, such as cell motility or stress responses, and has been implicated in pathologies ranging from cancer to neurodegeneration.
Gerasimos, Langousis, Jacint, Sanchez, Georg, Kempf, Patrick, Matthias   +3 more
openaire   +2 more sources

Dynamics of Endoglucanase Catalytic Domains: Implications Towards Thermostability

Journal of Biomolecular Structure and Dynamics, 2011
Thermostable endoglucanases play a crucial role in the production of biofuels to breakdown plant cellulose. Analyzing their structure-dynamics relationship can inform about the origins of their thermostability. Although tertiary structures of many endoglucanase proteins are available, the relationship between thermostability, structure, and dynamics is
Ragothaman M, Yennamalli, Jeffrey D, Wolt, Taner Z, Sen   +2 more
openaire   +2 more sources

Two catalytic domains of Chlorella virus CVK2 chitinase

Journal of Bioscience and Bioengineering, 2000
VChti-1 chitinase encoded by the Chlorella virus CVK2 contained two catalytic domains belonging to family 18 glycosyl hydrolases. The first catalytic domain on a C-terminal-truncated derivative of vChti-1 generated exclusively chitobiose from chitotetraose, chitohexaose, and colloidal high-molecular mass chitin in the enzyme reaction, a typical ...
S, Hiramatsu, M, Fujie, S, Usami, K, Sakai, T, Yamada   +4 more
openaire   +2 more sources

Universal Catalytic Domain Structure of AdoMet-dependent Methyltransferases

Journal of Molecular Biology, 1995
The DNA methyltransferases, M.HhaI and M.TaqI, and catechol O-methyl-transferase (COMT) catalyze the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (AdoMet) to carbon-5 of cytosine, to nitrogen-6 of adenine, and to a hydroxyl group of catechol, respectively. The catalytic domains of the bilobal proteins, M.HhaI and M.TaqI, and the
G, Schluckebier, M, O'Gara, W, Saenger, X, Cheng   +3 more
openaire   +2 more sources

Catalytic and Regulatory Domains of Doublecortin Kinase-1

Biochemistry, 2003
Doublecortin kinase-1 (DCK1) is a newly described multidomain protein kinase with a sequence significantly similar to those of both CaM kinases (CaMKs) and doublecortin, the product of the gene mutated in X-linked lissencephaly/double cortex syndrome, a severe developmental disorder of the nervous system.
Limin, Shang, Young-Guen, Kwon, Sandip, Nandy, David S, Lawrence, Arthur M, Edelman   +4 more
openaire   +2 more sources

Yeast adenylate cyclase catalytic domain is carboxy terminal

Current Genetics, 1986
Subcloning of DNA fragments from the gene coding for yeast adenylate cyclase has permitted, after complementation studies in S. cerevisiae cdc35 mutants as well as E. coli cya mutants, to identify the sequence coding for the catalytic domain of the protein.
P, Masson, G, Lenzen, J M, Jacquemin, A, Danchin   +3 more
openaire   +2 more sources

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

ChemBioChem, 2018
AbstractThe ten–eleven translocation (TET) protein family, consisting of three isoforms (TET1/2/3), have been found in mammalian cells and have a crucial role in 5‐methylcytosine demethylation in genomic DNA through the catalysis of oxidation reactions assisted by 2‐oxoglutarate (2OG). DNA methylation/demethylation contributes to the regulation of gene
Kosuke Nishio, Roman Belle, Takayuki Katoh, Akane Kawamura, Toru Sengoku, Kazuharu Hanada, Noboru Ohsawa, Mikako Shirouzu, Shigeyuki Yokoyama, Hiroaki Suga   +9 more
openaire   +3 more sources

Inhibitors of the catalytic domain of mitochondrial ATP synthase

Biochemical Society Transactions, 2006
An understanding of the mechanism of ATP synthase requires an explanation of how inhibitors act. The catalytic F1-ATPase domain of the enzyme has been studied extensively by X-ray crystallography in a variety of inhibited states. Four independent inhibitory sites have been identified by high-resolution structural studies.
J R, Gledhill, J E, Walker
openaire   +2 more sources

Structural analysis of the catalytic domain of tetanus neurotoxin

Toxicon, 2005
Clostridium neurotoxins, comprising the tetanus neurotoxin and the seven antigenically distinct botulinum neurotoxins (BoNT/A-G), are among the known most potent bacterial protein toxins to humans. Although they have similar function, sequences and three-dimensional structures, the substrate specificity and the selectivity of peptide bond cleavage are ...
Krishnamurthy N, Rao, Desigan, Kumaran, Thomas, Binz, Subramanyam, Swaminathan   +3 more
openaire   +2 more sources