Results 231 to 240 of about 349,791 (266)

Insertion of new sequences into the catalytic domain of an enzyme

Biochemistry, 1989
Activities of enzymes can be modified by the replacement of active-site amino acids with residues that strengthen specific interactions with substrates or that alter the specificity. The scope for engineered enzymes would be broadened if additional, new sequences could be inserted into a catalytic domain. Properly designed, these sequences could encode
R M, Starzyk, J J, Burbaum, P, Schimmel
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Crystal structure of the catalytic domain of a thermophilic endocellulase

Biochemistry, 1993
One way to improve the economic feasibility of biomass conversion is to enhance the catalytic efficiency of cellulases through protein engineering. This requires that high-resolution structures of cellulases be available. Here we present the structure of E2cd, the catalytic domain of the thermophilic endocellulase E2 from Thermomonospora fusca, as ...
M, Spezio, D B, Wilson, P A, Karplus
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Crystal Structure of the Catalytic Domain of Human ADAM33

Journal of Molecular Biology, 2004
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling.
Peter, Orth, Paul, Reichert, Wenyan, Wang, Winifred W, Prosise, Taisa, Yarosh-Tomaine, Gerald, Hammond, Richard N, Ingram, Li, Xiao, Urooj A, Mirza, Jun, Zou, Corey, Strickland, S Shane, Taremi, Hung V, Le, Vincent, Madison   +13 more
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Catalytic and Regulatory Domains of Doublecortin Kinase-1

Biochemistry, 2003
Doublecortin kinase-1 (DCK1) is a newly described multidomain protein kinase with a sequence significantly similar to those of both CaM kinases (CaMKs) and doublecortin, the product of the gene mutated in X-linked lissencephaly/double cortex syndrome, a severe developmental disorder of the nervous system.
Limin, Shang, Young-Guen, Kwon, Sandip, Nandy, David S, Lawrence, Arthur M, Edelman   +4 more
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Structure of the Isolated Catalytic Domain of Diphtheria Toxin

Biochemistry, 1995
The structure of the isolated catalytic domain of diphtheria toxin at pH 5.0 was determined by X-ray crystallography at 2.5 A resolution and refined to an R-factor of 19.7%. The domain is bound to its endogenous inhibitor adenylyl(3'-->5')uridine 3'-monophosphate (ApUp). The structure of this 190-residue domain, which was expressed in and isolated from
M S, Weiss, S R, Blanke, R J, Collier, D, Eisenberg   +3 more
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Structural analysis of the catalytic domain of tetanus neurotoxin

Toxicon, 2005
Clostridium neurotoxins, comprising the tetanus neurotoxin and the seven antigenically distinct botulinum neurotoxins (BoNT/A-G), are among the known most potent bacterial protein toxins to humans. Although they have similar function, sequences and three-dimensional structures, the substrate specificity and the selectivity of peptide bond cleavage are ...
Krishnamurthy N, Rao, Desigan, Kumaran, Thomas, Binz, Subramanyam, Swaminathan   +3 more
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Engineering the Catalytic Properties of Two-Domain Laccase from Streptomyces griseoflavus Ac-993

International Journal of Molecular Sciences, 2022
Kirill Kovalev, Azat Gabdulkhakov, Svetlana Tishchenko   +2 more
exaly  

A Single Catalytic Endolysin Domain Plychap001: Characterization and Application to Control Vibrio parahaemolyticus and Its Biofilm Directly

Foods, 2022
Jingxue Wang, Luokai Wang, Wang Jingxue   +2 more
exaly  

Structure of the catalytic domain of the

Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Tibisay Guevara, Miroslaw Ksiazek, Peter Durand Skottrup, Nýria Cerdý-Costa, Sergio Trillo-Muyo, Iýaki de Diego, Erik Riise, Jan Potempa, F   +8 more
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Virtual screening of natural compounds as selective inhibitors of polo-like kinase-1 at C-terminal polo box and N-terminal catalytic domain

Journal of Biomolecular Structure and Dynamics, 2022
Iwaloye Opeyemi, Olusola Elekofehinti, Femi Olawale   +2 more
exaly