Results 1 to 10 of about 850,773 (307)

Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease

Biomolecules, 2022
Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination.
Xin Pan, Sihua Wu, Wenping Wei, Zixuan Chen, Yong Wu, Kaizheng Gong   +5 more
doaj   +1 more source

Comparison of Biochemical Characteristics, Action Models, and Enzymatic Mechanisms of a Novel Exolytic and Two Endolytic Lyases with Mannuronate Preference

Marine Drugs, 2021
Recent explorations of tool-like alginate lyases have been focused on their oligosaccharide-yielding properties and corresponding mechanisms, whereas most were reported as endo-type with α-L-guluronate (G) preference.
Lianghuan Zeng, Junge Li, Yuanyuan Cheng, Dandan Wang, Jingyan Gu, Fuchuan Li, Wenjun Han   +6 more
doaj   +1 more source

Research Progress on Preparation of Marine Oligosaccharides by Enzymatic Method

Shipin gongye ke-ji, 2023
Marine oligosaccharides, which are prepared by degradation of marine polysaccharides, are carbohydrate compounds composed of two to ten monosaccharide residues.
Zixiang YANG, Jinmeng LI, Kunyan SONG, Fengru GE, Feng YAN, Bingbing HUANG, Mengyan ZHANG, Xiaodan WU, Yuhuan LIU, Hongli ZHENG   +9 more
doaj   +1 more source

Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications

Frontiers in Bioengineering and Biotechnology, 2020
Nitrile hydratase (NHase, EC 4.2.1.84) is one type of metalloenzyme participating in the biotransformation of nitriles into amides. Given its catalytic specificity in amide production and eco-friendliness, NHase has overwhelmed its chemical counterpart ...
Zhongyi Cheng, Yuanyuan Xia, Zhemin Zhou
doaj   +1 more source

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

eLife, 2020
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées   +10 more
doaj   +1 more source

Recent Progress of Electrochemical Production of Hydrogen Peroxide by Two‐Electron Oxygen Reduction Reaction

Advanced Science, 2021
Shifting electrochemical oxygen reduction reaction (ORR) via two‐electron pathway becomes increasingly crucial as an alternative/green method for hydrogen peroxide (H2O2) generation. Here, the development of 2e− ORR catalysts in recent years is reviewed,
Nan Wang, Shaobo Ma, Pengjian Zuo, Jizhou Duan, Baorong Hou   +4 more
doaj   +1 more source

CO2 reduction into formic acid under hydrothermal conditions: A mini review

Energy Science & Engineering, 2022
Converting CO2, a major component of greenhouse gas in the atmosphere, into value‐added fine chemicals is beneficial from environmental and economic aspects.
Xu Liu, Heng Zhong, Chunling Wang, Daoping He, Fangming Jin   +4 more
doaj   +1 more source

Family characteristics, phylogenetic reconstruction, and potential applications of the plant BAHD acyltransferase family

Frontiers in Plant Science, 2023
The BAHD acyltransferase family is a class of proteins in plants that can acylate a variety of primary and specialized secondary metabolites. The typically acylated products have greatly improved stability, lipid solubility, and bioavailability and thus ...
Donghuan Xu, Donghuan Xu, Zhong Wang, Weibing Zhuang, Tao Wang, Yinfeng Xie   +5 more
doaj   +1 more source

Structural and Mechanistic Insights Into Dimethylsulfoxide Formation Through Dimethylsulfide Oxidation

Frontiers in Microbiology, 2021
Dimethylsulfide (DMS) and dimethylsulfoxide (DMSO) are widespread in marine environment, and are important participants in the global sulfur cycle. Microbiol oxidation of DMS to DMSO represents a major sink of DMS in marine surface waters.
Xiu-Juan Wang, Xiu-Juan Wang, Xiu-Juan Wang, Nan Zhang, Zhao-Jie Teng, Peng Wang, Peng Wang, Wei-Peng Zhang, Xiu-Lan Chen, Xiu-Lan Chen, Yu-Zhong Zhang, Yu-Zhong Zhang, Yu-Zhong Zhang, Yin Chen, Yin Chen, Hui-Hui Fu, Chun-Yang Li, Chun-Yang Li   +17 more
doaj   +1 more source

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate [PDF]

, 2001
Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques(1). A catalytic mechanism, featuring a long-lived oxo-carbenium-ion intermediate, was proposed on the basis of model ...
A Federov, AL Fink, AT Brünger, BA Malcolm, BL Mark, CC Blake, Collaborative Computational Project Number 4, DC Phillips, DE Koshland, DM Chipman, E Holler, FW Ballardie, FW Dahlquist, G Sulzenbacher, GJ Davies, GJ Davies, GN Murshodov, I Matsumura, I Tews, ML Sinnott, NCJ Strynadka, Q Wang, R Kuroki, S Rosenberg, T Rand-Meir, TL Amyes, V Notenboom, WP Burmeister, Z Otwinowski   +28 more
core   +1 more source