Results 11 to 20 of about 850,773 (307)

Catalytic mechanisms for phosphotriesterases [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
Phosphotriesters are one class of highly toxic synthetic compounds known as organophosphates. Wide spread usage of organophosphates as insecticides as well as nerve agents has lead to numerous efforts to identify enzymes capable of detoxifying them. A wide array of enzymes has been found to have phosphotriesterase activity including phosphotriesterase (
Andrew N, Bigley, Frank M, Raushel
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Evolution of a Catalytic Mechanism [PDF]

Molecular Biology and Evolution, 2015
The means by which superfamilies of specialized enzymes arise by gene duplication and functional divergence are poorly understood. The escape from adaptive conflict hypothesis, which posits multiple copies of a gene encoding a primitive inefficient and highly promiscuous generalist ancestor, receives support from experiments showing that resurrected ...
Alissa, Rauwerdink, Mark, Lunzer, Titu, Devamani, Bryan, Jones, Joanna, Mooney, Zhi-Jun, Zhang, Jian-He, Xu, Romas J, Kazlauskas, Antony M, Dean   +8 more
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Representing Catalytic Mechanisms with Rule Composition

Journal of Chemical Information and Modeling, 2022
Preprint
Jakob L. Andersen, Rolf Fagerberg, Christoph Flamm, Walter Fontana, Juri Kolčák, Christophe V.F.P. Laurent, Daniel Merkle, Nikolai Nøjgaard   +7 more
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Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
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Glycoside Hydrolase Family 48 Cellulase: A Key Player in Cellulolytic Bacteria for Lignocellulose Biorefinery

Fermentation, 2023
Cellulases from glycoside hydrolase family 48 (GH48) are critical components of natural lignocellulose-degrading systems. GH48 cellulases are broadly distributed in cellulolytic microorganisms.
Cai You, Ya-Jun Liu, Qiu Cui, Yingang Feng   +3 more
doaj   +1 more source

UDP-Glycosyltransferases in Edible Fungi: Function, Structure, and Catalytic Mechanism

Fermentation, 2023
UDP-glycosyltransferases (UGTs) are the most studied glycosyltransferases, and belong to large GT1 family performing the key roles in antibiotic synthesis, the development of bacterial glycosyltransferase inhibitors, and in animal inflammation.
Yumeng Yang, Yingying Liang, Fengjie Cui, Yongli Wang, Lei Sun, Xinyi Zan, Wenjing Sun   +6 more
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Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria

Frontiers in Microbiology, 2017
Microbial cleavage of dimethylsulfoniopropionate (DMSP) producing dimethyl sulfide (DMS) and acrylate is an important step in global sulfur cycling. Acrylate is toxic for cells, and thus should be metabolized effectively for detoxification. There are two
Hai-Yan Cao, Peng Wang, Fei Xu, Ping-Yi Li, Bin-Bin Xie, Qi-Long Qin, Yu-Zhong Zhang, Yu-Zhong Zhang, Chun-Yang Li, Xiu-Lan Chen   +9 more
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A structural and biochemical model of processive chitin synthesis [PDF]

, 2014
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Andrew T. Ferenbach, Atkinson, Barny, Bond, Bowen, Cabib, Charnock, Coutinho, D'Haeze, Daan M.F. van Aalten, Debellé, Drew, Gaughran, Helge C. Dorfmueller, Imai, Kamst, Kamst, Kamst, Karnezis, Kathiravan, Källberg, Manoil, Martínez-Rucobo, Masubuchi, Mavingui, Morgan, Nagahashi, Orlean, Rao, Ruiz-Herrera, Semino, Shaw, Streng, Sudoh, Thompson, Uchida, Vladimir S. Borodkin, Xie, Yabe   +38 more
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MACiE: a database of enzyme reaction mechanisms. [PDF]

, 2005
SUMMARY: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create
Bartlett, Berman, D. E. Almonacid, G. J. Bartlett, G. L. Holliday, J. B. O. Mitchell, J. M. Thornton, Kanehisa, N. M. O'Boyle, Nagano, Orengo, P. Murray-Rust, Porter, Schomburg   +13 more
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Catalytic mechanism of thioltransferase

Journal of Biological Chemistry, 1991
To evaluate potential catalytic mechanism for thioltransferase thiol-disulfide exchange reactions, seven pig liver mutants were constructed by site-directed mutagenesis. All the expressed enzymes, including wild-type and mutants with the exception of the inactive mutant, ETT-C22S, were variably inhibited by iodoacetamide, and similar results were ...
Y F, Yang, W W, Wells
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