Results 11 to 20 of about 240,202 (291)
Catalytic promiscuity in the RNA World may have aided the evolution of prebiotic metabolism.
PLoS Computational Biology, 2021 The Metabolically Coupled Replicator System (MCRS) model of early chemical evolution offers a plausible and efficient mechanism for the self-assembly and the maintenance of prebiotic RNA replicator communities, the likely predecessors of all life forms ...
Dániel Vörös +2 more
doaj +1 more source
Frontiers in Chemistry, 2022 Three protein targets from SARS-CoV-2, the viral pathogen that causes COVID-19, are studied: the main protease, the 2′-O-RNA methyltransferase, and the nucleocapsid (N) protein. For the main protease, the nucleophilicity of the catalytic cysteine C145 is
Suhasini M. Iyengar +6 more
doaj +1 more source
F1000Research, 2016 Since the discovery of the first catalytic RNA in 1981, the field of ribozyme research has developed from the discovery of catalytic RNA motifs in nature and the elucidation of their structures and catalytic mechanisms, into a field of engineering and ...
Sabine Müller +4 more
doaj +1 more source
Modulation of RNase E activity by alternative RNA binding sites.
PLoS ONE, 2014 Endoribonuclease E (RNase E) affects the composition and balance of the RNA population in Escherichia coli via degradation and processing of RNAs. In this study, we investigated the regulatory effects of an RNA binding site between amino acid residues 25
Daeyoung Kim +8 more
doaj +1 more source
Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity
Cell Reports, 2013 We have solved the crystal structure of human ARGONAUTE1 (hAGO1) bound to endogenous 5′-phosphorylated guide RNAs. To identify changes that evolutionarily rendered hAGO1 inactive, we compared our structure with guide-RNA-containing and cleavage-active ...
Kotaro Nakanishi +8 more
doaj +1 more source
Crystal structure of an RNA-cleaving DNAzyme
Nature Communications, 2017 RNA-cleaving DNA enzymes are catalytic DNA that can cleave RNA in a sequence-specific manner. Here, the authors report three crystal structures of the 8–17 DNAzyme that include the pre-catalytic state of the RNA cleavage reaction, providing insight into ...
Hehua Liu +14 more
doaj +1 more source
Many Activities, One Structure: Functional Plasticity of Ribozyme Folds
Molecules, 2016 Catalytic RNAs, or ribozymes, are involved in a number of essential biological processes, such as replication of RNA genomes and mobile genetic elements, RNA splicing, translation, and RNA degradation.
Matthew W.L. Lau +1 more
doaj +1 more source
Frontiers in Microbiology, 2019 The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand ...
Hengxia Jia, Hengxia Jia, Peng Gong
doaj +1 more source
Evolution of RNA-protein interactions: non-specific binding led to RNA splicing activity of fungal mitochondrial tyrosyl-tRNA synthetases. [PDF]
PLoS Biology, 2014 The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new function as a group I intron splicing factor by acquiring the ability to bind group I intron RNAs and stabilize their catalytically active RNA structure ...
Lilian T Lamech +2 more
doaj +1 more source
The structure of an RNAi polymerase links RNA silencing and transcription.
PLoS Biology, 2006 RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression.
Paula S Salgado +5 more
doaj +1 more source