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NSUN7 is a catalytically inactive RNA m5C methyltransferase essential for sperm flagellum assembly
Nature CommunicationsRNA 5-methylcytosine (m5C) is a widespread RNA modification mainly catalyzed by the NSUN family, whose dysfunction is linked to various diseases. Among NSUN1-7, all possessing motifs IV and VI essential for RNA m5C formation, NSUN7’s catalytic activity ...
Jing Li +10 more
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Molecules, 2010 In vitro selection with long random RNA libraries has been used as a powerful method to generate novel functional RNAs, although it often requires laborious structural analysis of isolated RNA molecules.
Yuki Fujita +3 more
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Controlled evolution of an RNA enzyme [PDF]
It is generally thought that prior to the origin of protein synthesis, life on earth was based on self-replicating RNA molecules. This idea has become especially popular recently due to the discovery of catalytic RNA (ribozymes).
Joyce, G. F.
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Inhibition of HIV-1 Replication and Dimerization Interference by Dual Inhibitory RNAs
Molecules, 2010 The 5’-untranslated region (5’UTR) of the HIV-1 RNA is an attractive target for engineered ribozymes due to its high sequence and structural conservation.
Elena Puerta-Fernández +3 more
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High-throughput mutagenesis reveals unique structural features of human ADAR1
Nature Communications, 2020 Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesis ...
SeHee Park +9 more
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Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]
, 2009 A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath +3 more
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Catalytic Role for RNA in DNA Replication [PDF]
Nature New Biology, 1972 THERE are two biochemical systems which probably evolved before the development of accurate polynucleotide-specified protein synthesis: these are the system for polynucleotide replication and the machinery of protein synthesis itself1, 2. Before accurately specified proteins became available, these processes were perhaps catalysed by polynucleotide ...
openaire +2 more sources
Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+
Nature CommunicationsTpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of ...
Chulei Cao +17 more
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CHIMIA, 2018 Ribonuclease P (RNase P) is a class of enzymes involved in the processing of precursor tRNAs to remove their 5'-leader sequences. Ribonuclease P enzymes are classified into two completely distinct classes, i.e.
Yuri Nozawa +3 more
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In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei. [PDF]
Nucleic Acids Res, 2021 Dey A +7 more
europepmc +1 more source