Results 31 to 40 of about 249,749 (166)
RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis
Cell Reports, 2019 Summary: DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well as how its ATPase ...
Tri D. Ngo +2 more
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Catalytic RNA world relics in Dicer RNAs [PDF]
International Journal of Genetics, 2009 RNA interference (RNAi) is a naturally occurring phenomenon of RNA-mediated gene silencing that is highly conserved among multicellular organisms. In the first step of the pathway, long double- stranded RNA molecules are chopped into shorter duplexes with 2 nucleotide overhangs at both 3 ' ends by an endonuclease dubbed Dicer, the structure of which ...
Sayak Ganguli +5 more
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The Scientific World Journal, 2004 Ribozymes are functionally diverse RNA molecules with intrinsic catalytic activity. Multiple structural and biochemical studies are required to establish which nucleotide bases are involved in the catalysis.
Ivan Y. Torshin
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What RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental Attention
Life, 2015 We review arguments that biology emerged from a reciprocal partnership in which small ancestral oligopeptides and oligonucleotides initially both contributed rudimentary information coding and catalytic rate accelerations, and that the superior ...
Charles W. Carter
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RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway. [PDF]
PLoS ONE, 2014 Ribonuclease mitochondrial RNA processing (RNase MRP) is a multifunctional ribonucleoprotein (RNP) complex that is involved in the maturation of various types of RNA including ribosomal RNA.
Yuichiro Saito +8 more
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Ribozymes: the characteristics and properties of catalytic RNAs [PDF]
FEMS Microbiology Reviews, 1999 Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants. An example is also known of a ribozyme in hepatitis delta virus, a serious human pathogen.
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Structure Determination of Catalytic RNAs and Investigations of Their Metal Ion-Binding Properties
CHIMIA, 2005 Naturally occurring RNA molecules exhibit many unexpected and fascinating properties in living cells such as protein synthesis and transport, regulation of metabolic functions, and catalytic cleavage reactions.
Michèle C. Erat, Roland K.O. Sigel
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Origin & influence of autocatalytic reaction networks at the advent of the RNA world
RNA BiologyResearch on the origin of life investigates the transition from abiotic chemistry to the emergence of biology, with the ‘RNA world hypothesis’ as the leading theory. RNA’s dual role in storage and catalysis suggests its importance in this narrative.
Stephen A. Zorc, Raktim N. Roy
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Biology, 2017 A bimolecular ribozyme consisting of a core ribozyme (ΔP5 RNA) and an activator module (P5abc RNA) has been used as a platform to design assembled RNA nanostructures.
Md. Motiar Rahman +2 more
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RNA folding and catalysis mediated by iron (II). [PDF]
PLoS ONE, 2012 Mg²⁺ shares a distinctive relationship with RNA, playing important and specific roles in the folding and function of essentially all large RNAs. Here we use theory and experiment to evaluate Fe²⁺ in the absence of free oxygen as a replacement for Mg²⁺ in
Shreyas S Athavale +13 more
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