Results 51 to 60 of about 249,749 (166)
Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+
Nature CommunicationsTpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of ...
Chulei Cao +17 more
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CHIMIA, 2018 Ribonuclease P (RNase P) is a class of enzymes involved in the processing of precursor tRNAs to remove their 5'-leader sequences. Ribonuclease P enzymes are classified into two completely distinct classes, i.e.
Yuri Nozawa +3 more
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Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates
Nature CommunicationsMutations in the RNA helicase DDX3X, implicated in various cancers and neurodevelopmental disorders, often impair RNA unwinding and translation. However, the mechanisms underlying the impairment and the differential interactions of DDX3X mutants with ...
Michael C. Owens +9 more
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Reconciling Ligase Ribozyme Activity with Fatty Acid Vesicle Stability
Life, 2014 The “RNA world” and the “Lipid world” theories for the origin of cellular life are often considered incompatible due to the differences in the environmental conditions at which they can emerge.
Fabrizio Anella, Christophe Danelon
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The RNA World: Piecing together the historical development of a hypothesis
Mètode Science Studies Journal: Annual Review, 2016 The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
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Emergence of catalytic function in prebiotic information-coding polymers
eLifeLife as we know it relies on the interplay between catalytic activity and information processing carried out by biological polymers. Here we present a plausible pathway by which a pool of prebiotic information-coding oligomers could acquire an early ...
Alexei V Tkachenko, Sergei Maslov
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Fitness Landscapes and Evolution of Catalytic RNA
Annual Review of BiophysicsThe relationship between genotype and phenotype, or the fitness landscape, is the foundation of genetic engineering and evolution. However, mapping fitness landscapes poses a major technical challenge due to the amount of quantifiable data that is required.
Saha, Ranajay +3 more
openaire +4 more sources
The discovery of catalytic RNA [PDF]
Nature Reviews Molecular Cell Biology, 2017 openaire +2 more sources
Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. [PDF]
Nucleic Acids Res, 2018 Bao P +4 more
europepmc +1 more source
RNA targeting and cleavage by the type III-Dv CRISPR effector complex
Nature CommunicationsCRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction1–5.
Evan A. Schwartz +11 more
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