Results 41 to 50 of about 249,749 (166)
BMC BioinformaticsBackground Deoxyribozymes or DNAzymes represent artificial short DNA sequences bearing many catalytic properties. In particular, DNAzymes able to cleave RNA sequences have a huge potential in gene therapy and sequence-specific analytic detection of ...
M. Eremeyeva +3 more
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The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis
ExperimedThe RNA exosome complex is a multi-subunit ribonuclease complex that participates in RNA degradation, processing, and quality control. In recent years, mutations and dysregulation in the subunits of this complex, which play significant roles in RNA ...
Esra Nur Demirtaş +1 more
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Catalytic Role for RNA in DNA Replication [PDF]
Nature New Biology, 1972 THERE are two biochemical systems which probably evolved before the development of accurate polynucleotide-specified protein synthesis: these are the system for polynucleotide replication and the machinery of protein synthesis itself1, 2. Before accurately specified proteins became available, these processes were perhaps catalysed by polynucleotide ...
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RNA Catalytic Activity as a Probe of Chaperone-Mediated RNA Folding [PDF]
, 2013 For structured RNAs that possess catalytic activity, this activity provides a powerful probe for measuring the progress of folding and the effects of RNA chaperone proteins on the folding rate. The crux of this approach is that only the natively folded RNA is able to perform the catalytic reaction.
Brant, Gracia, Rick, Russell
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NSUN7 is a catalytically inactive RNA m5C methyltransferase essential for sperm flagellum assembly
Nature CommunicationsRNA 5-methylcytosine (m5C) is a widespread RNA modification mainly catalyzed by the NSUN family, whose dysfunction is linked to various diseases. Among NSUN1-7, all possessing motifs IV and VI essential for RNA m5C formation, NSUN7’s catalytic activity ...
Jing Li +10 more
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Biology, 2019 The modular structural domains of multidomain RNA enzymes can often be dissected into separate domain RNAs and their noncovalent assembly can often reconstitute active enzymes.
Yuri Nozawa +4 more
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Molecules, 2010 In vitro selection with long random RNA libraries has been used as a powerful method to generate novel functional RNAs, although it often requires laborious structural analysis of isolated RNA molecules.
Yuki Fujita +3 more
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In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei. [PDF]
Nucleic Acids Res, 2021 Dey A +7 more
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Inhibition of HIV-1 Replication and Dimerization Interference by Dual Inhibitory RNAs
Molecules, 2010 The 5’-untranslated region (5’UTR) of the HIV-1 RNA is an attractive target for engineered ribozymes due to its high sequence and structural conservation.
Elena Puerta-Fernández +3 more
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High-throughput mutagenesis reveals unique structural features of human ADAR1
Nature Communications, 2020 Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesis ...
SeHee Park +9 more
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