Structural basis of template-boundary definition in Tetrahymena telomerase. [PDF]
, 2015 Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template.
Akiyama, Ben M +5 more
core +2 more sources
RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates. [PDF]
PLoS ONE, 2014 RRP6 is a 3'-5' exoribonuclease associated to the eukaryotic exosome, a multiprotein complex essential for various RNA processing and degradation pathways.
Rosicler L Barbosa +5 more
doaj +1 more source
Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
, 2017 Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a B400 kDa five-subunit catalytic core.
Forrest, David +3 more
core +2 more sources
An Efficient Catalytic DNA that Cleaves L-RNA. [PDF]
PLoS ONE, 2015 Many DNAzymes have been isolated from synthetic DNA pools to cleave natural RNA (D-RNA) substrates and some have been utilized for the design of aptazyme biosensors for bioanalytical applications.
Kha Tram +3 more
doaj +1 more source
Twenty years of "Lipid World": a fertile partnership with David Deamer [PDF]
, 2019 "The Lipid World" was published in 2001, stemming from a highly effective collaboration with David Deamer during a sabbatical year 20 years ago at the Weizmann Institute of Science in Israel.
Kahana, Amit +2 more
core +1 more source
Catalytic RNA world relics in Dicer RNAs [PDF]
International Journal of Genetics, 2009 RNA interference (RNAi) is a naturally occurring phenomenon of RNA-mediated gene silencing that is highly conserved among multicellular organisms. In the first step of the pathway, long double- stranded RNA molecules are chopped into shorter duplexes with 2 nucleotide overhangs at both 3 ' ends by an endonuclease dubbed Dicer, the structure of which ...
Sayak Ganguli +5 more
openaire +1 more source
Mutational analysis of Trypanosoma brucei RNA editing ligase reveals regions critical for interaction with KREPA2. [PDF]
PLoS ONE, 2015 The Trypanosoma brucei parasite causes the vector-borne disease African sleeping sickness. Mitochondrial mRNAs of T. brucei undergo posttranscriptional RNA editing to make mature, functional mRNAs.
Vaibhav Mehta +3 more
doaj +1 more source
Ratcheted transport and sequential assembly of the yeast telomerase RNP
Cell Reports, 2023 Summary: The telomerase ribonucleoprotein particle (RNP) replenishes telomeric DNA and minimally requires an RNA component and a catalytic protein subunit.
Hannah Neumann +3 more
doaj +1 more source
Structural insights into the molecular mechanism of the m6A writer complex
eLife, 2016 Methylation of adenosines at the N6 position (m6A) is a dynamic and abundant epitranscriptomic mark that regulates critical aspects of eukaryotic RNA metabolism in numerous biological processes.
Paweł Śledź, Martin Jinek
doaj +1 more source
Expression of the C-terminal family 22 carbohydratebinding module of xylanase 10B of Clostridium themocellum in tobacco plant [PDF]
, 2009 Carbohydrate-binding modules have been shown to alter plant cell wall structural architecture. Hence, they have the potential application of being used to engineer the plant to produce tailor-made natural fibers in the cell wall.
Obembe, Olawole O.
core +2 more sources