Results 201 to 210 of about 389,745 (325)

Inhibition of UBE2C Promotes Parkin‐Mediated K63‐Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer

Advanced Science, EarlyView.
In the study, UBE2C was found to be significantly overexpressed in breast cancer and transcriptionally regulated by FOXM1. Inhibition of UBE2C suppressed proliferation, induced senescence, and sensitized breast cancer cells to doxorubicin. Mechanistically, UBE2C inhibition promoted Parkin‐mediated K63‐linked ubiquitination of TOP2A.
Yihui Yang, Wan Li, Hong Yang, Fang Xu, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Xiangyin Chi, Hongquan Wang, Guanhua Du, Yumin Wang, Jinhua Wang   +12 more
wiley   +1 more source

Demonstration of a Multistep Mechanism for Assembly of the SRP·SRP Receptor Complex: Implications for the Catalytic Role of SRP RNA [PDF]

, 2008
Xin Zhang, Simon Kung, Shu‐ou Shan
openalex   +1 more source

An Apple Susceptibility‐Related LRR Receptor‐Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans‐Kingdom Fungal microRNA‐Like RNA

Advanced Science, EarlyView.
The apple susceptibility‐related LRR‐RLK MdRLKT21 competitively binds to fungal sRNA effectors and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1. These findings provide new insights into the molecular mechanism by which plants counteract pathogen‐secreted sRNA ...
Mingliang Lei, Jian Zhang, Jie Wang, Chengyu Gao, Yanting He, Runze Tian, Hao Feng, Lili Huang   +7 more
wiley   +1 more source

Transcription Termination Factor Rho Prefers Catalytically Active Elongation Complexes for Releasing RNA [PDF]

, 2008
Dipak Dutta, Jisha Chalissery, Ranjan Sen   +2 more
openalex   +1 more source

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei, Qian Liu, Guoxin Liu, Manjie Zhang, Jiaxin Fang, Xuting He, Xueqi He, Zhengwei Qin, Ronghua Liu, Chuang Liu, Hongyu Ji, Yuechao Dong, Ye Yuan, Baofeng Yang, Weijie Du   +14 more
wiley   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA. [PDF]

Nat Commun
Wang DP, Zhao R, Hu WS, Li HN, Cao JM, Zhou X, Xiang Y.   +6 more
europepmc   +1 more source

Catalytic Activity as a Probe of Native RNA Folding [PDF]

, 2009
Yaqi Wan, David Mitchell, Rick Russell
openalex   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Opening new frontiers with catalytic nucleic acids in miRNA inhibition. [PDF]

Front Pharmacol
Patutina O, Miroshnichenko S, Chiglintseva D, Zenkova M.   +3 more
europepmc   +1 more source