Tailoring RNA modular units on a common scaffold: A modular ribozyme with a catalytic unit for β-nicotinamide mononucleotide-activated RNA ligation [PDF]
Yuki Fujita+2 more
openalex +1 more source
Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li+11 more
wiley +1 more source
Unraveling the Role of Topoisomerase 3β (TOP3B) in mRNA Translation and Human Disease. [PDF]
Warrick JE, Kearse MG.
europepmc +1 more source
Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang+10 more
wiley +1 more source
Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology. [PDF]
Wang L, Liu Y, Xian X, Zhang H.
europepmc +1 more source
Kinetic and functional analysis of the small RNA methyltransferase HEN1: The catalytic domain is essential for preferential modification of duplex RNA [PDF]
Giedrius Vilkaitis+2 more
openalex +1 more source
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian+9 more
wiley +1 more source
Molecular determinants of nucleic acid recognition by an RNA-targeting ADP-ribosyltransferase toxin. [PDF]
Lv F+4 more
europepmc +1 more source
The many faces of the hairpin ribozyme: Structural and functional variants of a small catalytic rna [PDF]
Sabine Müller+3 more
openalex +1 more source