Kinetic analysis of an efficient DNA-dependent TNA polymerase. [PDF]
, 2005 alpha-l-Threofuranosyl nucleoside triphosphates (tNTPs) are tetrafuranose nucleoside derivatives and potential progenitors of present-day beta-d-2'-deoxyribofuranosyl nucleoside triphosphates (dNTPs).
Chaput, John C +6 more
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Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives
Biomolecules, 2016 There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu +2 more
doaj +1 more source
RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates. [PDF]
PLoS ONE, 2014 RRP6 is a 3'-5' exoribonuclease associated to the eukaryotic exosome, a multiprotein complex essential for various RNA processing and degradation pathways.
Rosicler L Barbosa +5 more
doaj +1 more source
Machines on Genes: Enzymes that Make, Break and Move DNA and RNA [PDF]
, 2010 As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of remarkable ...
Bates +13 more
core +1 more source
Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting [PDF]
, 2010 Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both ...
Shan, Shu-ou, Shen, Kuang
core +3 more sources
Ribozymes: the characteristics and properties of catalytic RNAs [PDF]
FEMS Microbiology Reviews, 1999 Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants. An example is also known of a ribozyme in hepatitis delta virus, a serious human pathogen.
openaire +4 more sources
Error thresholds for self- and cross-specific enzymatic replication [PDF]
, 2010 The information content of a non-enzymatic self-replicator is limited by Eigen's error threshold. Presumably, enzymatic replication can maintain higher complexity, but in a competitive environment such a replicator is faced with two problems related to ...
Acevedo +56 more
core +4 more sources
Mutational analysis of Trypanosoma brucei RNA editing ligase reveals regions critical for interaction with KREPA2. [PDF]
PLoS ONE, 2015 The Trypanosoma brucei parasite causes the vector-borne disease African sleeping sickness. Mitochondrial mRNAs of T. brucei undergo posttranscriptional RNA editing to make mature, functional mRNAs.
Vaibhav Mehta +3 more
doaj +1 more source
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
core +1 more source
Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme. [PDF]
, 2020 Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its
Andreasson, Johan OL +3 more
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