Results 71 to 80 of about 389,745 (325)

Origin & influence of autocatalytic reaction networks at the advent of the RNA world

RNA Biology
Research on the origin of life investigates the transition from abiotic chemistry to the emergence of biology, with the ‘RNA world hypothesis’ as the leading theory. RNA’s dual role in storage and catalysis suggests its importance in this narrative.
Stephen A. Zorc, Raktim N. Roy
doaj   +1 more source

Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor. [PDF]

PLoS ONE, 2011
The RNA guanylyltransferase (GTase) is involved in the synthesis of the (m7)Gppp-RNA cap structure found at the 5' end of eukaryotic mRNAs. GTases are members of the covalent nucleotidyl transferase superfamily, which also includes DNA and RNA ligases ...
Maude Tremblay-Létourneau, Simon Despins, Isabelle Bougie, Martin Bisaillon   +3 more
doaj   +1 more source

RNA Conformation in Catalytically Active Human Telomerase [PDF]

Journal of the American Chemical Society, 2010
We have used single-molecule fluorescence microscopy to study the folded state of human telomerase RNA (hTR). Here we show that hTR adopts a new conformation on binding to human telomerase reverse transcriptase (hTERT) and reconstitution of an active ribonucleoprotein complex.
David Klenerman, Beth Ashbridge, Justin A. Yeoman, Angel Orte, Shankar Balasubramanian   +4 more
openaire   +3 more sources

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]

, 2006
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA–protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Aasland, Ahne, Akhtar, Andrew Flaus, Asturias, Auble, Auble, Auble, Bazett-Jones, Becker, Beerens, Bouazoune, Boyer, Boyer, Briggs, Caruthers, Corona, Cote, Dasgupta, Davis, Deaconescu, Dhalluin, Dumont, Durr, Eisen, Fan, Fitzgerald, Flaus, Flaus, Goldmark, Gorbalenya, Grune, Harald Dürr, Havas, Hishida, Ito, Jaskelioff, Kagalwala, Karl-Peter Hopfner, Kawaoka, Kim, Laurent, Laurent, Levin, Levin, Lia, Mahdi, Mannhaupt, Mizuguchi, Morillon, Myong, Peterson, Petukhova, Petukhova, Phelan, Pray-Grant, Quinn, Richmond, Ristic, Saha, Saha, Schild, Sengoku, Serebrov, Shen, Shinohara, Simic, Sims, Singleton, Singleton, Singleton, Smith, Soultanas, Sprouse, Stanley, Studitsky, Subramanya, Sukhodolets, Svejstrup, Swagemakers, Tai, Thoma, Tom Owen-Hughes, Tran, Tsukiyama, van den Boom, van Gool, Van Komen, Velankar, Wang, Whitehouse, Woudstra, Yu, Yu, Zhang, Zofall   +95 more
core   +3 more sources

Evolution of catalytic rna in the laboratory [PDF]

Origins of life and evolution of the biosphere, 1989
We are interested in the biochemistry of existing RNA enzymes and in the development of RNA enzymes with novel catalytic function. The focal point of our research program has been the design and operation of a laboratory system for the controlled evolution of catalytic RNA.
openaire   +2 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

SequenceCraft: machine learning-based resource for exploratory analysis of RNA-cleaving deoxyribozymes

BMC Bioinformatics
Background Deoxyribozymes or DNAzymes represent artificial short DNA sequences bearing many catalytic properties. In particular, DNAzymes able to cleave RNA sequences have a huge potential in gene therapy and sequence-specific analytic detection of ...
M. Eremeyeva, Y. Din, N. Shirokii, N. Serov   +3 more
doaj   +1 more source

Generation and Development of RNA Ligase Ribozymes with Modular Architecture Through “Design and Selection”

Molecules, 2010
In vitro selection with long random RNA libraries has been used as a powerful method to generate novel functional RNAs, although it often requires laborious structural analysis of isolated RNA molecules.
Yuki Fujita, Junya Ishikawa, Hiroyuki Furuta, Yoshiya Ikawa   +3 more
doaj   +1 more source