Subcutaneous Levodopa in Parkinson's Disease: A Systematic Review and Meta‐Analysis
European Journal of Neurology, Volume 33, Issue 2, February 2026.ABSTRACT Background Many Parkinson's disease patients receiving oral levodopa/carbidopa experience a troublesome wearing off effect. Higher doses to mitigate OFF‐time are limited by adverse effects occurring at peak dopamine levels, particularly dyskinesia.
Matthew Burton +6 more
wiley +1 more source
Tetranuclear Copper(Ii) Complexes as Mimics of Catechol Oxidase
, 2022 M UMAYAL, Govindasamy Mugesh
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Distribution, regulation and physiological roles of catechol-O-methyltransferase (COMT) in rodents [PDF]
, 2012 Catechol-O-methyltransferase (COMT) metabolises catecholamines such as dopamine, noradrenaline and adrenaline, which are well-characterised neurotransmitters that play important roles in the regulation of physiological processes.
Schendzielorz, Nadia
core
Borneo Journal of PharmacyParkinson's disease is a global health challenge affecting over 10 million individuals worldwide, leading to increased disability-adjusted life years (DALYs) and a rise in mortality rates. This study explores the potential anti-Parkinson's properties of
Riyan Alifbi Putera Irsal +4 more
doaj +1 more source
Correction to: Metformin-based copper(II) complexes: synthesis, structural characterization and mimicking activity of catechol oxidase and phenoxazinone synthase [PDF]
, 2021 Abd El‐Motaleb M. Ramadan +5 more
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, 2013 Background: Bacteria of the genus Arthrobacter are ubiquitous in soil environments and can be considered as true survivalists. Arthrobacter sp. strain Rue61a is an isolate from sewage sludge able to utilize quinaldine (2- methylquinoline) as sole carbon ...
Daniel, R. (Rolf) +6 more
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Archives of Medical Science, 2006 Introduction: Attention-deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It is
Pavel Theiner +6 more
doaj
Dynamics of Adaptive Microevolution of Hypermutable Pseudomonas aeruginosa during Chronic Pulmonary Infection in Patients with Cystic Fibrosis [PDF]
, 2009 Eichner, Anja +7 more
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HeliyonNicotine, the main compound in cigarettes, leads to smoking addiction. Nicotine acts on the limbic dopamine reward loop in the midbrain by binding to nicotinic acetylcholine receptors, promoting the release of dopamine, and resulting in a rewarding ...
Jingjing Yang +4 more
doaj +1 more source
The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene [PDF]
, 2021 Yemiao Gao +3 more
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