Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]
, 2009 The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine +51 more
core +4 more sources
Beyond brown: Polyphenol oxidases as enzymes of plant specialized metabolism
Frontiers in Plant Science, 2015 Most cloned and/or characterized plant polyphenol oxidases (PPOs) have catechol oxidase activity (i.e. they oxidize o-diphenols to o-quinones) and are localized or predicted to be localized to plastids.
Michael L Sullivan
doaj +1 more source
The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging [PDF]
, 2006 Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in ...
Bernstein, HG +9 more
core +1 more source
Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives [PDF]
, 2014 Alcohol consumption is associated with an increased risk of breast cancer, increasing linearly even with a moderate consumption and irrespectively of the type of alcoholic beverage.
Castro, Gerardo Daniel +1 more
core +1 more source
Effect of carrot puree edible films on quality preservation of fresh-cut carrots [PDF]
, 2015 peer-reviewedFinancial support from the high level talent fund of Henan University of Technology Science and Technology (No. 2012BS024) is gratefully acknowledged.The effect of edible films based on carrot puree, chitosan, corn starch, gelatin, glycerol ...
Kong, D. +3 more
core +1 more source
Bananas decrease acetaminophen potency in in vitro assays. [PDF]
PLoS ONE, 2018 Edible portions of bananas contain high levels of polyphenol oxidase, which catalyzes reactions in the melanin formation pathway. Tyrosine, a physiological substrate of polyphenol oxidase, has an analogous structure to acetaminophen.
Yoshihiro Uesawa, Naotaka Tsuji
doaj +1 more source
MONOAMINE OXIDASE AND CATECHOL- O-METHYLTRANSFERASE INHIBITORS
Medical Clinics of North America, 1999 Despite advances in the treatment of PD, there remain significant unmet therapeutic needs. This is particularly true at the later stages of the disease when dopaminergic therapy is complicated by motor fluctuations and dyskinesias. Inhibition of dopamine metabolism is a valuable adjunct to exogenous dopaminergic replacement.
A, Siderowf, R, Kurlan
openaire +2 more sources
Rate enhancement of the catechol oxidase activity of a series of biomimetic monocopper(II) complexes by introduction of non-coordinating groups in N-tripodal ligands [PDF]
, 2012 International audienceAsymmetrical N-tripodal ligands have been synthesized in three steps. Diversity has been introduced at the first step of the synthesis by adding pyrazine, pyridine, benzyl and thiophene rings.
Floner, Didier +5 more
core +4 more sources
Chemosensors, 2014 Inhibition-based biosensors were developed by immobilizing tyrosinase (Tyr, polyphenol oxidase) from the crude extract of avocado fruit on electrochemically prepared polypyrrole (PPy) films.
André Brisolari, Débora Gonçalves
doaj +1 more source
eNeurologicalSci, 2020 Background: Dopamine replacement therapy is an established treatment for motor symptoms of Parkinson's disease, but its long-term use is often limited by the eventual development of motor complications, including levodopa-induced dyskinesia.
Shoko Kakinuma +19 more
doaj +1 more source