Results 61 to 70 of about 34,133 (279)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Xanthine Oxidase Inhibition and Anti-LDL Oxidation by Prenylated Isoflavones from Flemingia philippinensis Root

Molecules, 2020
Xanthine oxidase is a frontier enzyme to produce oxidants, which leads to inflammation in the blood. Prenylated isoflavones from Flemingia philippinensis were found to display potent inhibition against xanthine oxidase (XO).
Jeong Yoon Kim, Yan Wang, Zuo Peng Li, Aizhamal Baiseitova, Yeong Jun Ban, Ki Hun Park   +5 more
doaj   +1 more source

Structural and spectroscopic studies of a model for catechol oxidase [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2008
A binuclear copper complex, [Cu2(BPMP) (OAc)2][ClO4] x H2O, has been prepared using the binucleating ligand 2,6-bis[bis(pyridin-2-ylmethylamino)methyl]-4-methylphenol (H-BPMP). The X-ray crystal structure reveals the copper centers to have a five-coordinate square pyramidal geometry, with the acetate ligands bound terminally.
Smith, S. J., Noble, C. J., Palmer, R. C., Hanson, G. R., Schenk, Gerhard, Gahan, L. R., Riley, M. J.   +6 more
openaire   +4 more sources

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications. [PDF]

Angew Chem Int Ed Engl
The dual redox nature of polyphenols enables antioxidant activity and controlled reactive oxygen species (ROS) generation. This review details the biomedical applications of polyphenols in materials such as nanoparticles, coatings, and hydrogels for antimicrobial, tissue regeneration, and cancer therapies.
Bolaños-Cardet J, Pepió-Tárrega B, Saiz-Poseu J, López-Moral A, Ullah F, Yuste VJ, Ruiz-Molina D, Suárez-García S.   +7 more
europepmc   +3 more sources

Soil Response to Agricultural Land Abandonment: A Case Study of a Vineyard in Northern Italy

Agronomy, 2021
Agricultural land abandonment is an emerging problem in European Union (EU), and about 11% of agricultural EU land is at high risk of abandonment in the coming 10 years. Land abandonment may have both positive and negative effects in ecosystems.
Luigi Sciubba, Martina Mazzon, Luciano Cavani, Elena Baldi, Moreno Toselli, Claudio Ciavatta, Claudio Marzadori   +6 more
doaj   +1 more source

Mussel‐Bioinspired Edible Ca2+‐Crosslinked Alginate Hydrogel Electrodes for Glucose Gastrointestinal Monitoring

Advanced Science, EarlyView.
A fully edible soft electrode is engineered from Ca2⁺‐crosslinked alginate integrated with polydopamine, silver nanoparticles, and food‐grade glucose oxidase. The hybrid hydrogel combines ionic and electronic conduction, enabling efficient glucose‐to‐H2O2 conversion and catalytic reduction in simulated intestinal fluid.
Verdiana Marchianò, Claudio Pellegrini, Angelo Tricase, Eleonora Macchia, Andrea Brattelli, Luigi Gentile, Patrizia Nadia Hanieh, Noemi Fiaschini, Antonio Rinaldi, Luisa Torsi, Paolo Bollella   +10 more
wiley   +1 more source

Oxygen Activation by Mononuclear Mn, Co, and Ni Centers in Biology and Synthetic Complexes [PDF]

, 2017
The active sites of metalloenzymes that catalyze O2-dependent reactions generally contain iron or copper ions. However, several enzymes are capable of activating O2 at manganese or nickel centers instead, and a handful of dioxygenases exhibit activity ...
Fiedler, Adam T., Fischer, Anne A.
core   +1 more source

Are Large Physiological Reactions to Acute Psychological Stress Always Bad for Health? [PDF]

, 2009
How we react physiologically to stress has long been considered to have implications for our health. There is now persuasive evidence that individuals who show large cardiovascular reactions to stress are at increased risk of developing cardiovascular ...
Acheson, Adolphs, Allen, Al’Absi, Al’Absi, Al’Absi, Anisman, Bachen, Barch, Barnett, Bechara, Beck, Blair, Bosch, Bosch, Bosch, Brydon, Buchanan, Cacioppo, Caldji, Carney, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Caspi, Critchley, Cuthbert, Damasio, Damasio, De Boer, De Boer, Dhabhar, Dhabhar, Ditto, Drummond, Edwards, Edwards, Edwards, Edwards, Enoch, Everson, Everson, Fredrikson, Gagnon, Georgiades, Gianaros, Gianaros, Girdler, Glahn, Goldman, Grassi, Hemingway, Idler, Ishiguro, Kanitz, Kapuku, Kario, Kario, Kibler, Kirschbaum, Kirschbaum, Kirschbaum, Krantz, Lazarus, Leor, Lesch, Light, Lipsky, Liu, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lowe, Lynch, Maier, Manuck, Manuck, Manuck, Manuck, Markovitz, Matthews, Matthews, Meaney, Meaney, Meisel, Mesulam, Millan, Miller, Mischler, Moss, Muldoon, Murdison, Naqvi, Newman, Obrist, Panknin, Patterson, Patterson, Phillips, Phillips, Phillips, Phillips, Phillips, Plotsky, Pomerleau, Rohleder, Rolls, Roy, Schwartz, Sheffield, Silberman, Sims, Smith, Smolka, Sorocco, Straneva, Tentolouris, Tentolouris, Tofler, Treiber, Treiber, Trichopoulos, Tuchscherer, Turner, Ungerleider, Vandenbergh, Welle, Williams, Williams, Witte, Wulsin, York, Zgraggen, Zigmond, Zubieta   +144 more
core   +2 more sources