Results 81 to 90 of about 19,268 (196)
Biosensors, 2018 In this work, an innovative polyphenol oxidase biosensor was developed from Jenipapo (Genipa americana L.) fruit and used to assess phenolic compounds in industrial effluent samples obtained from a textile industry located in Jaraguá-GO, Brasil.
Rafael Souza Antunes +7 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib +3 more
wiley +1 more source
Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis
Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala +2 more
wiley +1 more source
Purification and characterization of polyphenol oxidase (PPO) from water yam (Dioscorea alata)
CyTA - Journal of Food, 2019 Polyphenol oxidase (PPO) is responsible for the enzymatic browning of fruits and vegetables, and thus has negative effects on the quality of food. In this study, extraction and purification of PPO from water yam was performed successfully, and the ...
Xinyan Peng +5 more
doaj +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, Volume 13, Issue 47, 24 August 2026.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Acta Medica BulgaricaCurrent treatment for Parkinson’s disease (PD) includes: levodopa, dopamine agonists, monoamine oxidase type B inhibitors, catechol-O-methyltransferase inhibitors, amantadine, anticholinergics, clozapine and deep brain stimulation. A lot of patients with
Yankov G., Ilieva V.
doaj +1 more source
Current treatments in Parkinson's including the proposal of an innovative dopamine microimplant
Revista Médica del Hospital General de México, 2016 Parkinson's disease is a chronic, debilitating, progressive neurological disorder of multifactorial origin. It affects between 0.3% and 2% of the over-65 population worldwide, with a predilection for men, and is characterised by bradykinesia, muscular ...
M. Velázquez-Paniagua +3 more
doaj +1 more source
Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy
Advanced Science, Volume 13, Issue 45, 13 August 2026.ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang +10 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo +5 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 8, August 2026.Green and variegated Alternanthera bettzickiana morphotypes were compared after optimizing extraction (Box–Behnken design–RSM: 90% ethanol, 50°C, 2 h, 10 mg/mL). The green morphotype had higher phenolic content, FRAP, and ORAC activity, while the variegated morphotype had higher flavonoid and anthocyanin content.
Sirinapa Thangsiri +5 more
wiley +1 more source