Results 81 to 90 of about 20,124 (183)

A Cu-bis(imidazole) Substrate Intermediate Is the Catalytically Competent Center for Catechol Oxidase Activity of Copper Amyloid-β. [PDF]

Inorg Chem, 2021
Bacchella C, Dell'Acqua S, Nicolis S, Monzani E, Casella L.   +4 more
europepmc   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Ultra‐Tough Hybrid Supramolecular Gelatin Hydrogels

Small, Volume 22, Issue 61, 2 November 2026.
Tannic acid‐mediated coacervation compacts gelatin into a dense supramolecular network while generating an acidic microenvironment that activates pre‐embedded bis‐oxazoline crosslinkers. The resulting hybrid hydrogel combines covalent stabilization with reversible energy dissipation, producing high strength, extreme extensibility, substantial toughness,
Patrick Shakari, Christos Leliopoulos, Hamidreza Mokhtari, Rohith Pavan Parvathaneni, Afroditi Kontse, Jöns Hilborn, Oommen P. Varghese   +6 more
wiley   +1 more source

Development of a Polyphenol Oxidase Biosensor from Jenipapo Fruit Extract (Genipa americana L.) and Determination of Phenolic Compounds in Textile Industrial Effluents

Biosensors, 2018
In this work, an innovative polyphenol oxidase biosensor was developed from Jenipapo (Genipa americana L.) fruit and used to assess phenolic compounds in industrial effluent samples obtained from a textile industry located in Jaraguá-GO, Brasil.
Rafael Souza Antunes, Denes Ferraz, Luane Ferreira Garcia, Douglas Vieira Thomaz, Rafael Luque, Germán Sanz Lobón, Eric de Souza Gil, Flávio Marques Lopes   +7 more
doaj   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Perioperative Treatment with High Dose Rotigotine and Amantadine Combination in a Patient with Advanced Stage Parkinson’s Disease After Esophagectomy

Acta Medica Bulgarica
Current treatment for Parkinson’s disease (PD) includes: levodopa, dopamine agonists, monoamine oxidase type B inhibitors, catechol-O-methyltransferase inhibitors, amantadine, anticholinergics, clozapine and deep brain stimulation. A lot of patients with
Yankov G., Ilieva V.
doaj   +1 more source

Purification and characterization of polyphenol oxidase (PPO) from water yam (Dioscorea alata)

CyTA - Journal of Food, 2019
Polyphenol oxidase (PPO) is responsible for the enzymatic browning of fruits and vegetables, and thus has negative effects on the quality of food. In this study, extraction and purification of PPO from water yam was performed successfully, and the ...
Xinyan Peng, Chao Du, Haiyang Yu, Xiaoyu Zhao, Xiuyuan Zhang, Xiaoyu Wang   +5 more
doaj   +1 more source

Identification of Amino Acid Residues Responsible for C-H Activation in Type-III Copper Enzymes by Generating Tyrosinase Activity in a Catechol Oxidase. [PDF]

Angew Chem Int Ed Engl, 2020
Kampatsikas I, Pretzler M, Rompel A.
europepmc   +1 more source

Molecular Docking and Dynamics of Xylocarpus granatum as A Potential Parkinson’s Drug Targeting Multiple Enzymes

Borneo Journal of Pharmacy
Parkinson's disease is a global health challenge affecting over 10 million individuals worldwide, leading to increased disability-adjusted life years (DALYs) and a rise in mortality rates. This study explores the potential anti-Parkinson's properties of
Riyan Alifbi Putera Irsal, Gusnia Meilin Gholam, Dzikri Anfasa Firdaus, Novian Liwanda, Fernanda Chairunisa   +4 more
doaj   +1 more source

Original paper
Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Archives of Medical Science, 2006
Introduction: Attention-deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It is
Pavel Theiner, Ivana Drtilkova, Radim Stafi, William Didden, Renata Pitelova, Vladimir Mikes, Omar Sery   +6 more
doaj