Results 151 to 160 of about 6,632,351 (302)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Towards a category theory approach to analogy: Analyzing re-representation and acquisition of numerical knowledge. [PDF]
PLoS Comput Biol, 2017 Navarrete JA, Dartnell P.
europepmc +1 more source
A tangent category approach to operadic geometry
In his Lectures on Noncommutative Geometry, Ginzburg proposes a theory of algebraic noncommutative (affine) geometry. One of the fundamental insights of noncommutative geometry is to regard associative, non necessarily commutative, algebras as geometric ...
Lanfranchi, Marcello
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Modeling Reusable and Interoperable Faceted Browsing Systems with Category Theory. [PDF]
Proc IEEE Int Conf Inf Reuse Integr, 2015 Harris DR.
europepmc +1 more source
Introduction to Category Theory [PDF]
, 2004 A brief introduction to the general idea behind category theory with some basic definitions and examples.
Bousquet, O.
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Category Theory and Galois Theory Category Theory and Galois Theory
, 2020 . Galois theory translates questions about fields into questions about groups. The fundamental theorem of Galois theory states that there is a bijection between the intermediate fields of a field extension and the subgroups of the corresponding Galois ...
Amanda Bower
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
The co-smash product as an intrinsic tensor product [PDF]
, 2014 While the co-smash product of objects in a semi-abelian category may be used as a formal commutator [2, 3], ever since its introduction in [1] it has also been clear that certain tensor products appear as co-smash products.
Van der Linden, Tim +1 more
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