Results 141 to 150 of about 329,157 (308)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Category Theory for Autonomous and Networked Dynamical Systems. [PDF]
Entropy (Basel), 2019 Delvenne JC.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Fundamental Concepts of Category Theory [PDF]
, 1970 ii, 32 p.This paper will not go into what is being done in category theory. Its purpose is to give a clear picture of the essential terms of the theory: category, functor and natural ...
Hocker, Walter
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Category Free Category Theory and Its Philosophical Implications [PDF]
, 2016 There exists a dispute in philosophy, going back at least to Leibniz, whether is it possible to view the world as a network of relations and relations between relations with the role of objects, between which these relations hold, entirely eliminated ...
Heller, Michael
core +1 more source
Foundations of reusable and interoperable facet models using category theory. [PDF]
Inf Syst Front, 2016 Harris DR.
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Towards a category theory approach to analogy: Analyzing re-representation and acquisition of numerical knowledge. [PDF]
PLoS Comput Biol, 2017 Navarrete JA, Dartnell P.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source