Results 121 to 130 of about 6,408,999 (296)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Extending Undirected Graph Techniques to Directed Graphs via Category Theory
MathematicsWe use Category Theory to construct a ‘bridge’ relating directed graphs with undirected graphs, such that the notion of direction is preserved. Specifically, we provide an isomorphism between the category of simple directed graphs and a category we call ‘
Sebastian Pardo-Guerra +4 more
doaj +1 more source
Abstract Homotopy Theory and the Thomason Model structure [PDF]
, 2016 There is a closed model structure on the category of small categories, called Thomason model structure, that is Quillen equivalent to the standard model structure on the category of topological spaces.
Bruckner, Roman
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A tangent category approach to operadic geometry
In his Lectures on Noncommutative Geometry, Ginzburg proposes a theory of algebraic noncommutative (affine) geometry. One of the fundamental insights of noncommutative geometry is to regard associative, non necessarily commutative, algebras as geometric ...
Lanfranchi, Marcello
core
On split extensions of bialgebras
, 2018 Inspired by the discovery in [3] that the category of cocommutative Hopf algebras over an algebraically closed field is semi-abelian, in the article [2] we prove a universal characterisation of Hopf algebras amongst cocommutative bialgebras. It is of the
Van der Linden, Tim +1 more
core
A role for the developing lexicon in phonetic category acquisition [PDF]
, 2013 Infants learn to segment words from fluent speech during the same period as they learn native language phonetic categories, yet accounts of phonetic category acquisition typically ignore information about the words in which sounds appear.
Morgan, James L. +3 more
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source