Results 101 to 110 of about 6,632,351 (302)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Systematicity and a categorical theory of cognitive architecture: universal construction in context

Frontiers in Psychology, 2016
Why does the capacity to think certain thoughts imply the capacity to think certain other, structurally related, thoughts? Despite decades of intensive debate, cognitive scientists have yet to reach a consensus on an explanation for this property of ...
Steven Phillips, William Wilson
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Oriented Category Theory

As categorical dimension increases, classical categorical concepts often become too rigid and must be replaced by appropriately lax analogues. A basic manifestation of this principle is that higher-categorical versions of familiar geometric constructions -- such as cylinders, cones, and suspensions -- are not functorial in the classical sense.
Gepner, D. ; https://orcid.org/0000-0002-7825-9579, Heine, H.   +1 more
openaire   +3 more sources

Robert Rosen’s Relational Biology Theory and His Emphasis on Non-Algorithmic Approaches to Living Systems

Mathematics
This paper examines the use of algorithms and non-algorithmic models in mathematics and science, especially in biology, during the past century by summarizing the gradual development of a conceptual rationale for non-algorithmic models in biology. First,
Patricia A. Lane
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Category Theory and Galois Theory [PDF]

, 2017
Galois theory translates questions about fields into questions about groups. The fundamental theorem of Galois theory states that there is a bijection between the intermediate fields of a field extension and the subgroups of the corresponding Galois ...
Bower, Amanda
core   +1 more source

No categorial support for radical ontic structural realism [PDF]

, 2013
Radical ontic structural realism (ROSR) asserts an ontological commitment to 'free-standing' physical structures understood solely in terms of fundamental relations, without any recourse to relata which stand in these relations.
Lam, Vincent, Wuthrich, Christian
core   +1 more source

Enriching Laser Powder Bed Fusion Part Data Using Category Theory

Journal of Manufacturing and Materials Processing
Laser powder bed fusion (LPBF) is a promising metal additive manufacturing technology for producing functional components. However, there are still a lot of obstacles to overcome before this technology is considered mature and trustworthy for wider ...
Yuchu Qin, Shubhavardhan Ramadurga Narasimharaju, Qunfen Qi, Shan Lou, Wenhan Zeng, Paul J. Scott, Xiangqian Jiang   +6 more
doaj   +1 more source

Negating as turning upside down

Studies in Logic, Grammar and Rhetoric, 2018
In order to understand negation as such, at least since Aristotle’s time, there have been many ways of conceptually modelling it. In particular, negation has been studied as inconsistency, contradictoriness, falsity, cancellation, an inversion of ...
Skowron Bartłomiej, Kubiś Wiesław
doaj   +1 more source