Results 101 to 110 of about 329,157 (308)

Robert Rosen’s Relational Biology Theory and His Emphasis on Non-Algorithmic Approaches to Living Systems

open access: yesMathematics
This paper examines the use of algorithms and non-algorithmic models in mathematics and science, especially in biology, during the past century by summarizing the gradual development of a conceptual rationale for non-algorithmic models in biology. First,
Patricia A. Lane
doaj   +1 more source

Open Markov Processes: A Compositional Perspective on Non-Equilibrium Steady States in Biology

open access: yesEntropy, 2016
In recent work, Baez, Fong and the author introduced a framework for describing Markov processes equipped with a detailed balanced equilibrium as open systems of a certain type.
Blake S. Pollard
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Category Theory and Galois Theory Category Theory and Galois Theory [PDF]

open access: yes, 2020
. Galois theory translates questions about fields into questions about groups. The fundamental theorem of Galois theory states that there is a bijection between the intermediate fields of a field extension and the subgroups of the corresponding Galois ...
Amanda Bower
core  

EEG decoding of semantic category reveals distributed representations for single concepts [PDF]

open access: yes, 2011
Here we present a collection of advanced data-mining techniques that allows the semantics of individual concepts to be decoded from single trials of EEG data. Neural activity was recorded while participants silently named images of mammals and tools, and
Murphy, B.   +22 more
core   +1 more source

Enriching Laser Powder Bed Fusion Part Data Using Category Theory

open access: yesJournal of Manufacturing and Materials Processing
Laser powder bed fusion (LPBF) is a promising metal additive manufacturing technology for producing functional components. However, there are still a lot of obstacles to overcome before this technology is considered mature and trustworthy for wider ...
Yuchu Qin   +6 more
doaj   +1 more source

An Order-Theoretic Quantification of Contextuality

open access: yesInformation, 2014
In this essay, I develop order-theoretic notions of determinism and contextuality on domains and topoi. In the process, I develop a method for quantifying contextuality and show that the order-theoretic sense of contextuality is analogous to the sense ...
Ian T. Durham
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

A role for the developing lexicon in phonetic category acquisition [PDF]

open access: yes, 2013
Infants learn to segment words from fluent speech during the same period as they learn native language phonetic categories, yet accounts of phonetic category acquisition typically ignore information about the words in which sounds appear.
Morgan, James L.   +3 more
core  

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