Results 101 to 110 of about 6,408,999 (296)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A characterization of central extensions in the variety of quandles
, 2017 During the last years some categorical properties of the category Qnd of quandles have been investigated. We shall first recall some of these results that will be useful for the present work, and then consider the subvariety SymQnd of Qnd consisting in ...
International Category Theory Conference 2017 +1 more
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The co-smash product as an intrinsic tensor product [PDF]
, 2014 While the co-smash product of objects in a semi-abelian category may be used as a formal commutator [2, 3], ever since its introduction in [1] it has also been clear that certain tensor products appear as co-smash products.
Van der Linden, Tim +1 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
“Is logic a physical variable?” Introduction to the Special Issue
Zagadnienia Filozoficzne w Nauce, 2020 “Is logic a physical variable?” This thought-provoking question was put forward by Michael Heller during the public lecture “Category Theory and Mathematical Structures of the Universe” delivered on 30th March 2017 at the National Quantum Information ...
Michał Eckstein, Bartłomiej Skowron
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Infinitesimal Structure of Singularities
Universe, 2017 Some important problems of general relativity, such as the quantisation of gravity or classical singularity problems, crucially depend on geometry on very small scales.
Michael Heller, Jerzy Król
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Category Theory-Based Mobile User Interface Pattern Recommendation Method
IEEE Access, 2019 Although using the mobile user interface pattern (MUIP) can increase the efficiency and quality of mobile interface development, the existing pattern search methods have some limitations to provide appropriate patterns for solving a given design problem.
Wei Jia +5 more
doaj +1 more source
Restriction Category Perspectives of Partial Computation and Geometry
, 2017 This thesis introduces several structures based on Cockett and Lack’s restriction categories which find applications in partial computation, geometry, topology and two-dimensional category theory.
DeWolf, Darien
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