Results 91 to 100 of about 2,362,169 (271)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Formalizing Structural Semiotics: A Category-Theoretic Approach to Actantial Systems
AxiomsIn this article we present a categorical reconstruction of the actantial model introduced by A. J. Greimas in structural semiotics. Using Spivak and Kent’s framework of ontological logs and schema-based categories, the actantial system is formalized as a
Michael Fowler
doaj +1 more source
Infinitesimal Structure of Singularities
Universe, 2017 Some important problems of general relativity, such as the quantisation of gravity or classical singularity problems, crucially depend on geometry on very small scales.
Michael Heller, Jerzy Król
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Journal of Physics: ComplexityThis paper introduces a category theory-based framework to redefine physical computing in light of advancements in quantum computing and non-standard computing systems.
Nima Dehghani, Gianluca Caterina
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Semi-Substructural Logics à la Lambek with Symmetry
Bulletin of the Section of LogicThis work studies the proof theory and ternary relational semantics of left (right) skew monoidal closed categories and skew monoidal bi-closed categories, both symmetric and non-symmetric, from the perspective of non-associative Lambek calculus ...
Cheng-Syuan Wan
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Category Theory-Based Mobile User Interface Pattern Recommendation Method
IEEE Access, 2019 Although using the mobile user interface pattern (MUIP) can increase the efficiency and quality of mobile interface development, the existing pattern search methods have some limitations to provide appropriate patterns for solving a given design problem.
Wei Jia +5 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Coinductive Streams in Monoidal Categories [PDF]
Logical Methods in Computer ScienceWe introduce monoidal streams. Monoidal streams are a generalization of causal stream functions, which can be defined in cartesian monoidal categories, to arbitrary symmetric monoidal categories. In the same way that streams provide semantics to dataflow
Elena Di Lavore +2 more
doaj +1 more source