Results 91 to 100 of about 6,408,999 (296)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Category-Theory-Guided Conditional Diffusion Modeling for Climate-Responsive Architectural Spatial Layout Generation

open access: yesBuildings
Achieving robust environmental responsiveness in early stage architectural spatial layout design remains a critical challenge under the imperatives of global carbon neutrality and climate-adaptive building practice.
Rui Liu, Xiaofei Lu
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Robert Rosen’s Relational Biology Theory and His Emphasis on Non-Algorithmic Approaches to Living Systems

open access: yesMathematics
This paper examines the use of algorithms and non-algorithmic models in mathematics and science, especially in biology, during the past century by summarizing the gradual development of a conceptual rationale for non-algorithmic models in biology. First,
Patricia A. Lane
doaj   +1 more source

Open Markov Processes: A Compositional Perspective on Non-Equilibrium Steady States in Biology

open access: yesEntropy, 2016
In recent work, Baez, Fong and the author introduced a framework for describing Markov processes equipped with a detailed balanced equilibrium as open systems of a certain type.
Blake S. Pollard
doaj   +1 more source

Oriented Category Theory

open access: yes
As categorical dimension increases, classical categorical concepts often become too rigid and must be replaced by appropriately lax analogues. A basic manifestation of this principle is that higher-categorical versions of familiar geometric constructions -- such as cylinders, cones, and suspensions -- are not functorial in the classical sense.
Gepner, D. ; https://orcid.org/0000-0002-7825-9579   +1 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Enriching Laser Powder Bed Fusion Part Data Using Category Theory

open access: yesJournal of Manufacturing and Materials Processing
Laser powder bed fusion (LPBF) is a promising metal additive manufacturing technology for producing functional components. However, there are still a lot of obstacles to overcome before this technology is considered mature and trustworthy for wider ...
Yuchu Qin   +6 more
doaj   +1 more source

An Order-Theoretic Quantification of Contextuality

open access: yesInformation, 2014
In this essay, I develop order-theoretic notions of determinism and contextuality on domains and topoi. In the process, I develop a method for quantifying contextuality and show that the order-theoretic sense of contextuality is analogous to the sense ...
Ian T. Durham
doaj   +1 more source

Challenging the role of implicit processes in probabilistic category learning [PDF]

open access: yes, 2007
Considerable interest in the hypothesis that different cognitive tasks recruit qualitatively distinct processing systems has led to the proposal of separate explicit (declarative) and implicit (procedural) systems.
Lagnado, DA, Shanks, DR, Newell, BR
core  

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