Results 71 to 80 of about 2,362,169 (271)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Level-Agnostic Representations of Interacting Agents
MathematicsThe study of the interactions among intentional agents, with rationality being the main source of intentional behavior, requires mathematical tools capable of capturing systemic effects. Here, we choose an alternative toolbox based on Category Theory. We
Fernando Tohmé, Andrés Fioriti
doaj +1 more source
MENS, an Info-Computational Model for (Neuro-)cognitive Systems Capable of Creativity
Entropy, 2012 MENS is a bio-inspired model for higher level cognitive systems; it is an application of the Memory Evolutive Systems developed with Vanbremeersch to model complex multi-scale, multi-agent self-organized systems, such as biological or social systems. Its
Andrée C. Ehresmann
doaj +1 more source
, 2023 We establish and advocate for a novel branch of category theory, centered around strong dinatural transformations (herein known as "paranatural transformations"). Paranatural transformations generalize natural transformations to mixed-variant difunctors, but, unlike other such generalizations, are composable and exceptionally well-behaved.
openaire +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
MathematicsThis paper examines the use of algorithms and non-algorithmic models in mathematics and science, especially in biology, during the past century by summarizing the gradual development of a conceptual rationale for non-algorithmic models in biology. First,
Patricia A. Lane
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Enriching Laser Powder Bed Fusion Part Data Using Category Theory
Journal of Manufacturing and Materials ProcessingLaser powder bed fusion (LPBF) is a promising metal additive manufacturing technology for producing functional components. However, there are still a lot of obstacles to overcome before this technology is considered mature and trustworthy for wider ...
Yuchu Qin +6 more
doaj +1 more source
Ring completion of rig categories
, 2009 We offer a solution to the long-standing problem of group completing within the context of rig categories (also known as bimonoidal categories). Given a rig category R we construct a natural additive group completion R' that retains the multiplicative ...
Baas, Nils A. +3 more
core +1 more source