Results 71 to 80 of about 6,408,999 (296)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
String Diagrams for Premonoidal Categories [PDF]
Logical Methods in Computer SciencePremonoidal categories are monoidal categories without the interchange law while effectful categories are premonoidal categories with a chosen monoidal subcategory of interchanging morphisms. In the same sense that string diagrams, pioneered by Joyal and
Mario Román, Paweł Sobociński
doaj +1 more source
Compactly Generated Domain Theory [PDF]
, 2006 We propose compactly generated monotone convergence spaces as a well-behaved topological generalisation of directed-complete partial orders (dcpos). The category of such spaces enjoys the usual properties of categories of 'predomains' in denotational ...
Battenfeld, Ingo +2 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Level-Agnostic Representations of Interacting Agents
MathematicsThe study of the interactions among intentional agents, with rationality being the main source of intentional behavior, requires mathematical tools capable of capturing systemic effects. Here, we choose an alternative toolbox based on Category Theory. We
Fernando Tohmé, Andrés Fioriti
doaj +1 more source
Zagadnienia Filozoficzne w Nauce, 2022 The unusual applicability of mathematics to the description of the physical reality still remains a major investigative task for philosophers, physicists, mathematicians and cognitive scientists.
Wojciech Grygiel
doaj
On the category of cocommutative Hopf algebras
, 2019 In [1] we prove that the category of cocommutative Hopf algebras over any field is semi-abelian [2]. The aim of this talk is to give an idea of the proof of this result and to explain some of its consequences.
Sterck, Florence, Category theory 2019
core
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source