Results 61 to 70 of about 2,362,169 (271)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Filozoficznie prowokująca teoria kategorii

Zagadnienia Filozoficzne w Nauce, 2018
Recenzja książki: Elaine Landry (red.), Categories for the Working Philosopher, Oxford University Press, Oxford, 2017, ss. xiv+471.
Michał Heller
doaj  

A critical analysis of the philosophical motivations and development of the concept of the field of rationality as a representation of the fundamental ontology of the physical reality

Zagadnienia Filozoficzne w Nauce, 2022
The unusual applicability of mathematics to the description of the physical reality still remains a major investigative task for philosophers, physicists, mathematicians and cognitive scientists.
Wojciech Grygiel
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Category Theory

This book provides a deep foray into category theory, presenting a unique approach to exploring diverse branches of mathematics. From the fundamentals, where the definitions of morphism, object and composition in categories are established, to the application of these concepts in real analysis, linear algebra and general topology, my purpose is to ...
  +5 more sources

Entropy, Information and Complexity or Which Aims the Arrow of Time?

Entropy, 2015
In this article, we analyze the interrelationships among such notions as entropy, information, complexity, order and chaos and show using the theory of categories how to generalize the second law of thermodynamics as a law of increasing generalized ...
George E. Mikhailovsky, Alexander P. Levich   +1 more
doaj   +1 more source

A General Framework for the Semantics of Type Theory

, 2019
We propose an abstract notion of a type theory to unify the semantics of various type theories including Martin-L\"{o}f type theory, two-level type theory and cubical type theory.
Uemura, Taichi
core  

Homotopy theory with *-categories

Theory and Applications of Categories, 2019
We construct model category structures on various types of (marked) *-categories. These structures are used to present the infinity categories of (marked) *-categories obtained by inverting (marked) unitary equivalences. We use this presentation to explicitly calculate the \infty-categorical G-fixed points and G-orbits for G-equivariant (marked ...
openaire   +2 more sources