Results 91 to 100 of about 411,716 (331)

Acetylation of β-Catenin by p300 Regulates β-Catenin-Tcf4 Interaction [PDF]

Molecular and Cellular Biology, 2004
Lysine acetylation modulates the activities of nonhistone regulatory proteins and plays a critical role in the regulation of cellular gene transcription. In this study, we showed that the transcriptional coactivator p300 acetylated beta-catenin at lysine 345, located in arm repeat 6, in vitro and in vivo.
Lévy, Laurence, Wei, Yu, Labalette, Charlotte, Wu, Yuanfei, Renard, Claire-Angélique, Buendia, Marie Annick, Neuveut, Christine   +6 more
openaire   +3 more sources

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. [PDF]

PLoS ONE, 2010
The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin ...
Maree C Faux, Janine L Coates, Nadia J Kershaw, Meredith J Layton, Antony W Burgess   +4 more
doaj   +1 more source

Immunohistochemical analysis of E-cadherin,  -catenin,  -catenin,  -catenin, and neural cell adhesion molecule (NCAM) in chordoma [PDF]

Journal of Clinical Pathology, 2001
Aims—the epithelioid features seen in chordoma are unique among mesenchymal tumours. However, no detailed analysis regarding cell–cell communication has been conducted in this epithelioid tumour. The aims of this study were to investigate cell–cell communication in chordoma.
T Naka, Y Oda, Y Iwamoto, N Shinohara, H Chuman, M Fukui, M Tsuneyoshi   +6 more
openaire   +1 more source

Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]

, 2016
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D, Jiang, Yan, Nguyen, Thai, Oda, Yuko, Tu, Chia-Ling   +4 more
core   +2 more sources

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Cell Reports, 2015
Some cancer cells exhibit elevated levels of free fatty acids (FAs) as well as high levels of β-catenin, a transcriptional co-activator that promotes their growth. Here, we link these two phenomena by showing that unsaturated FAs inhibit degradation of β-
Hyeonwoo Kim, Carlos Rodriguez-Navas, Rahul K. Kollipara, Payal Kapur, Ivan Pedrosa, James Brugarolas, Ralf Kittler, Jin Ye   +7 more
doaj   +1 more source

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Molecular Brain, 2019
Alzheimer’s disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival.
Lin Jia, J. Piña-Crespo, Yonghe Li
semanticscholar   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

δ-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases. [PDF]

PLoS ONE, 2015
δ-Catenin, an adherens junctions protein, is not only involved in early development, cell-cell adhesion and cell motility in neuronal cells, but it also plays an important role in vascular endothelial cell motility and pathological angiogenesis.
Sampa Ghose, Yongfen Min, P Charles Lin
doaj   +1 more source