Results 81 to 90 of about 95,571 (251)

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.

PLoS Biology, 2020
Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood.
Mudan He, Ru Zhang, Shengbo Jiao, Fenghua Zhang, Ding Ye, Houpeng Wang, Yonghua Sun   +6 more
doaj   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Table5_Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells.xlsx

, 2023
Introduction: Wnt/β-catenin signaling controls cell division and lineage specification during embryonic development, and is crucial for stem cells maintenance and gut tissue regeneration in adults.
Irina Elcheva (3844003), Vonn Walter (165501), Vladimir S. Spiegelman (10308404), Yuka Imamura Kawasawa (7254923), Vikash Singh (387413)   +4 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

DataSheet1_Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells.docx

, 2023
Introduction: Wnt/β-catenin signaling controls cell division and lineage specification during embryonic development, and is crucial for stem cells maintenance and gut tissue regeneration in adults.
Irina Elcheva (3844003), Vonn Walter (165501), Vladimir S. Spiegelman (10308404), Yuka Imamura Kawasawa (7254923), Vikash Singh (387413)   +4 more
core   +1 more source

Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity

Cell Death and Disease
The aberrant Wnt/β-catenin signaling is tightly associated with developmental disorders and tumorigenesis. However, spatial regulation of cytoplasmic β-catenin with regard to its nuclear accumulation and signaling activation remains poorly understood ...
Muhah Jeong, Shin-Hyeon Ryu, Young-Sin Cho, Do-Hyeong Na, Jongyeon Baek, Jihoon Nah, Ki Woo Kim, Yong-Keun Jung   +7 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

EGFR and WNT/β-catenin signalling in airway homeostasis and repair [PDF]

, 2011
Lung cancers are a leading cause of death worldwide, and although there is some evidence that both Epidermal Growth Factor Receptor (EGFR) and Wnt/β-catenin signalling are involved in initiation and progression of this disease the molecular mechanisms
Lu, L.
core  

Aberrant nuclear localization of β-catenin without genetic alterations in β-catenin or Axin genes in esophageal cancer

World Journal of Surgical Oncology, 2007
Background β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation.
Shinoda Noriyuki, Sugiura Hironori, Terashita Yukio, Shibata Yasuyuki, Ishiguro Hideyuki, Haruki Nobuhiro, Nishiwaki Tadashi, Kudo Junzo, Kimura Masahiro, Kuwabara Yoshiyuki, Fujii Yoshitaka   +10 more
doaj   +1 more source

A schematic diagram showing hypothetical conformational changes of the cadherin-catenin-actin complex under force.

, 2018
A) A cartoon of the complex. In the absence of a crystal structure of the entirety, the diagram is drawn from the following PDB structures of various components: 3Q2V (E-cadherin), 3L6X (p120 catenin), 1I7W (β-catenin), 4IGG (αE-catenin), 1M8Q (F-actin).
Jacob Moran (5641529), Christopher Weddle (5641532), Shishir Adhikari (5641526), Michael Hinczewski (2737891)   +3 more
core   +1 more source