Results 81 to 90 of about 411,716 (331)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity [PDF]

Journal of Biological Chemistry, 2007
Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signaling,
Dexing, Fang, David, Hawke, Yanhua, Zheng, Yan, Xia, Jill, Meisenhelder, Heinz, Nika, Gordon B, Mills, Ryuji, Kobayashi, Tony, Hunter, Zhimin, Lu   +9 more
openaire   +2 more sources

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]

, 2019
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna, Goh, Ryan, Kong, Xiangyu, Liu, Lizhong, Warmflash, Aryeh   +4 more
core   +1 more source

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis.
Xiao-xiao Cheng, Xiang-ming Xu, Dong Chen, Feng Zhao, Weilin Wang   +4 more
semanticscholar   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Nuclear p120 catenin is a component of the perichromosomal layer and coordinates sister chromatid segregation during mitosis in lung cancer cells

Cell Death and Disease, 2022
Abnormal expression of p120 catenin is associated with the malignant phenotype in human lung cancer. Numerous studies have focused on the function of p120 catenin in the juxta-membrane compartment.
Shu-Er Chow, Yaa-Jyuhn J. Meir, Jhy-Ming Li, Ping-Chih Hsu, Cheng-Ta Yang   +4 more
doaj   +1 more source

α-Catenin overrides Src-dependent activation of β-catenin oncogenic signaling [PDF]

Molecular Cancer Therapeutics, 2008
Abstract Loss of α-catenin is one of the characteristics of prostate cancer. The catenins (α and β) associated with E-cadherin play a critical role in the regulation of cell-cell adhesion. Tyrosine phosphorylation of β-catenin dissociates it from E-cadherin and facilitates its entry into the nucleus, where β-catenin acts as a ...
Landon J, Inge, Sigrid A, Rajasekaran, Daniel, Wolle, Sonali P, Barwe, Sergey, Ryazantsev, Charles M, Ewing, William B, Isaacs, Ayyappan K, Rajasekaran   +7 more
openaire   +2 more sources

Wnt/beta-catenin pathway: modulating anticancer immune response

Journal of Hematology & Oncology, 2017
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.
S. Pai, B. Carneiro, J. M. Mota, R. Costa, C. A. Leite, R. Barroso-Sousa, J. Kaplan, Y. Chae, F. Giles   +8 more
semanticscholar   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

β-Catenin regulates endocardial cushion growth by suppressing p21

Life Science Alliance, 2023
This work demonstrates that β-catenin–mediated suppression of p21 is essential for endocardial cushion formation, suggesting a potential role of β-catenin in the etiology of congenital heart defects.
Huahua Liu, Pengfei Lu, Shan He, Yuru Luo, Yuan Fang, Sonia Benkaci, Bingruo Wu, Yidong Wang, Bin Zhou   +8 more
doaj   +1 more source